PMID: 8584505Aug 1, 1995Paper

Transfer of lidocaine and bupivacaine across the isolated perfused human placenta

Pharmacology & Toxicology
T I Ala-KokkoK Vähäkangas

Abstract

Drug permeability and pharmacokinetics through the placenta are important factors determining foetal drug exposure. The purpose of the present study was to establish a perfused human placental cotyledon system to assess the placental transfer of lidocaine and bupivacaine, widely used local anaesthetics in obstetric anaesthesia. Term placentas were obtained immediately after delivery with maternal consent and a two-hour recycling perfusion of a single placental cotyledon was performed. Bupivacaine or lidocaine with antipyrine as a reference compound were added to the maternal reservoir and their disappearance from the maternal circulation and appearance to the foetal circulation were followed in five experiments for each drug. Drug concentrations were measured by gas chromatography. Bupivacaine disappeared more rapidly from the maternal circulation than lidocaine. At 2 hr, bupivacaine foetal:maternal concentration ratio was 0.56 +/- 0.12 and 14.6% +/- 2.99 of the total circulating amount was found in the foetal circulation. Lidocaine concentration increased more in the foetal circulation and the foetal:maternal concentration ratio at 2 hr was 0.90 +/- 0.09 (P < 0.01), and 22.1% +/- 2.21 (P < 0.01) was found in the foetal circula...Continue Reading

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Citations

Jul 1, 1997·International Journal of Obstetric Anesthesia·T I Ala-KokkoK Vähäkangas
Feb 28, 2004·Journal of Pharmacological and Toxicological Methods·P Myllynen, K Vähäkangas
Mar 17, 2007·SAR and QSAR in Environmental Research·M HewittM T D Cronin
Feb 1, 1997·Acta Anaesthesiologica Scandinavica·T I Ala-KokkoK Vähäkangas
Jun 2, 2004·Clinical Pharmacokinetics·Michael R SymeJeffrey A Keelan
Sep 6, 2003·Paediatric Drugs·Jay E MattinglyJaya Ramanathan
Sep 15, 2004·European Journal of Clinical Pharmacology·Ricardo de Carvalho CavalliSérgio Pereira da Cunha
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
May 15, 2010·Toxicology Letters·Vesa KarttunenKirsi Vähäkangas
Apr 15, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·H PagèsB Guillois
Jul 13, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Maja MyrenLisbeth Ehlert Knudsen
Aug 3, 2006·Journal of Biomedical Materials Research. Part a·Lauren FlynnKimberly A Woodhouse
Sep 19, 2015·Toxicology Letters·Suvi K SoininenMarika Ruponen
Jan 23, 1999·American Journal of Obstetrics and Gynecology·E S LampelaK H Vähäkangas
Jul 1, 2018·British Journal of Clinical Pharmacology·Rodrigo Metzker Pereira RibeiroGeraldo Duarte
Sep 20, 1996·American Journal of Medical Genetics·S J TsiourisF J McMahon
Oct 1, 2005·Alternatives to Laboratory Animals : ATLA·Susanne BremerHorst Spielmann

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