Transfer of maternally injected endocrine disruptors through breast milk during lactation induces neonatal Calbindin-D9k in the rat model

Reproductive Toxicology
Eui-Ju HongEui-Bae Jeung

Abstract

The uterus is a highly estrogen-responsive tissue, which can be measured through changes in CaBP-9k expression. In this study, we investigated the potential for estrogenic compounds 4-tert-octylphenol (OP), nonylphenol (NP), bisphenol A (BPA), diethylstilbestrol (DES) and 17beta-estradiol (E2) to be transferred through breast milk from dam to neonate during lactation using the induction of CaBP-9k in uterine tissue as a biomarker. Dams were treated with OP, NP and BPA, dissolved in corn oil, at doses of 200, 400 and 600 mg/kg body weight per day l for 5 days after delivery. Dams and neonates were euthanized after 24h. Treatment with these estrogenic compounds increased the expression of CaBP-9k mRNA in the maternal uterus, in a dose-dependent manner. All doses of estrogenic compounds resulted in an increase in CaBP-9k protein levels. These compounds have an estrogenic effect on the maternal uterus during the lactation period as shown by the induction of both CaBP-9k mRNA and protein. In the neonatal uterus, the expression of CaBP-9k mRNA and protein significantly increased with DES exposure. There was a significant increase in CaBP-9k mRNA in neonatal uterus when the dams were treated with high doses of estrogenic compounds, bu...Continue Reading

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Citations

Nov 18, 2005·Reproductive Biology and Endocrinology : RB&E·Kyung-Chul ChoiEui-Bae Jeung
Mar 3, 2010·Environmental Health Perspectives·Nicoletta BechiLuana Paulesu
Aug 6, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thuy T B Vo, Eui-Bae Jeung
Jan 12, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S B SainathP Sreenivasula Reddy
Aug 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Geun-Shik LeeEui-Bae Jeung
Jul 10, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert E ChapinSusan R Woskie
Jun 15, 2012·Animal Science Journal = Nihon Chikusan Gakkaihō·Michihisa UedaShinichi Kume
Jun 2, 2015·Molecular and Cellular Endocrinology·Antonella SpagnolettiFrancesca Ietta
Jan 8, 2016·Dose-response : a Publication of International Hormesis Society·Chiara MannelliLuana Paulesu
Mar 24, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven CooperK Barry Delclos
Aug 28, 2009·Toxicology Mechanisms and Methods·I RykowskaJ Lulek
Apr 16, 2008·Environment International·N AdemolloE Funari

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