Transfer of parahydrogen-induced hyperpolarization to 19F

The Journal of Physical Chemistry. a
Lars T KuhnJoachim Bargon

Abstract

Homogeneous hydrogenations of unsaturated substrates with parahydrogen yield strong NMR signal enhancements of the transferred 1H nuclei if the symmetry of H2 is broken in the resulting hydrogenated products. This chemically induced hyperpolarization known as Parahydrogen-induced polarization (PHIP) is also transferred to other protons and heteronuclei (2H, 13C, 29Si, 31P) when the hydrogenation is initiated at low magnetic fields. Hydrogenating various fluorinated styrenes and phenylacetylenes, we show that PHIP-derived hyperpolarization is transferred to 19F not only in the Earth's magnetic field (ALTADENA condition) but also in a strong magnetic field, e.g., when carrying out the reaction in the NMR spectrometer (PASADENA condition). Upon conducting a systematic analysis of the observed PHIP transfer to 1H, 13C, and 19F in the hydrogenation products to elucidate the mechanisms that govern this parahydrogen-aided resonance transfer (PART), we conclude that high- and low-field PHIP transfer mechanisms differ in detail depending on either through-bond or through-space interactions. Substrates with high hydrogenation rates and long spin-lattice relaxation times (T1) yield the highest degree of heteronuclear hyperpolarization. Po...Continue Reading

References

Apr 25, 2001·Journal of Magnetic Resonance·M Goldman
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K GolmanJ S Petersson
Jul 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jonas SvenssonLars E Olsson
Dec 2, 2004·The British Journal of Radiology·K GolmanJ S Petersson
Apr 19, 2005·Magnetic Resonance Imaging·Maurice GoldmanMagnus Karlsson

❮ Previous
Next ❯

Citations

Aug 17, 2010·Analytical and Bioanalytical Chemistry·Silvia Paasch, Eike Brunner
Aug 13, 2013·Journal of Magnetic Resonance·Stefan GlögglerStephan Appelt
Dec 22, 2009·Physical Chemistry Chemical Physics : PCCP·S E KorchakH-M Vieth
Jul 9, 2010·Physical Chemistry Chemical Physics : PCCP·Ute BommerichJohannes Bernarding
Jul 25, 2013·Physical Chemistry Chemical Physics : PCCP·Alexey S KiryutinNikita N Lukzen
Apr 25, 2008·The Journal of Chemical Physics·Konstantin L IvanovHans-Martin Vieth
Aug 22, 2014·Progress in Nuclear Magnetic Resonance Spectroscopy·Konstantin L IvanovRobert Kaptein
Mar 24, 2015·Journal of Magnetic Resonance·Andrey N PravdivtsevHans-Martin Vieth
Jun 18, 2016·Chemical Communications : Chem Comm·Amy J Ruddlesden, Simon B Duckett
May 24, 2018·Chemistry, an Asian Journal·Kirill V KovtunovIgor V Koptyug
Feb 28, 2018·Angewandte Chemie·Jan-Bernd HövenerEduard Y Chekmenev
May 13, 2008·Magnetic Resonance in Chemistry : MRC·Meike RothAchim Koch
Oct 4, 2012·NMR in Biomedicine·Christopher Witte, Leif Schröder
Jul 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Todd K StevensAlex Pines
Jun 26, 2012·Magnetic Resonance in Chemistry : MRC·Silvano EllenaSilvio Aime
Mar 26, 2013·Chemistry : a European Journal·Markus PlaumannJohannes Bernarding
Jun 21, 2014·Physical Chemistry Chemical Physics : PCCP·P TürschmannS Appelt
Jan 7, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Neil J Stewart, Shingo Matsumoto
Oct 29, 2020·Chemistry : a European Journal·Baptiste JoallandEduard Y Chekmenev
Apr 21, 2021·Physical Chemistry Chemical Physics : PCCP·Bogdan A RodinKonstantin L Ivanov
Aug 1, 2019·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Oleg G SalnikovEduard Y Chekmenev
Aug 1, 2013·The Journal of Physical Chemistry Letters·Alexey S KiryutinKonstantin L Ivanov
Oct 26, 2018·Journal of the American Chemical Society·Kenan TokmicAlison R Fout

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Klaes GolmanJ Stefan Petersson
© 2021 Meta ULC. All rights reserved