Transfer of photosynthetic NADP+ /NADPH recycling activity to a porous metal oxide for highly specific, electrochemically-driven organic synthesis

Chemical Science
Bhavin SiritanaratkulFraser A Armstrong

Abstract

In a discovery of the transfer of chloroplast biosynthesis activity to an inorganic material, ferredoxin-NADP+ reductase (FNR), the pivotal redox flavoenzyme of photosynthetic CO2 assimilation, binds tightly within the pores of indium tin oxide (ITO) to produce an electrode for direct studies of the redox chemistry of the FAD active site, and fast, reversible and diffusion-controlled interconversion of NADP+ and NADPH in solution. The dynamic electrochemical properties of FNR and NADP(H) are thus revealed in a special way that enables facile coupling of selective, enzyme-catalysed organic synthesis to a controllable power source, as demonstrated by efficient synthesis of l-glutamate from 2-oxoglutarate and NH4+.

References

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Sep 10, 2014·Journal of the American Chemical Society·Andreas BachmeierFraser A Armstrong

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Citations

Nov 15, 2018·Chemical Society Reviews·Rhiannon M EvansFraser A Armstrong
Apr 11, 2018·Chemistry : a European Journal·Nicholas D J YatesAlison Parkin
Aug 11, 2017·Chemical Communications : Chem Comm·Ceren ZorKylie A Vincent
Jan 11, 2018·Chemical Communications : Chem Comm·Lei WanFraser A Armstrong
Mar 19, 2019·Nature·Alison Narayan
Aug 30, 2020·Sensors·Taiki AdachiKenji Kano
Sep 19, 2020·ChemSusChem·Michael RichterVolker Sieber
Jan 14, 2021·Nature Communications·Giorgio MorelloFraser A Armstrong
Dec 16, 2020·The Journal of Chemical Physics·Clare F MegarityFraser A Armstrong
Apr 13, 2021·Nature Catalysis·Steffen HardtNicolas Plumeré
Jun 9, 2021·Nature Communications·Jinxing ChenShaojun Dong
Jun 25, 2020·Journal of the American Chemical Society·Liyun ZhangFraser A Armstrong
Dec 5, 2019·Accounts of Chemical Research·Ross D Milton, Shelley D Minteer
Nov 11, 2021·Bioscience, Biotechnology, and Biochemistry·Kenji Kano
Jan 26, 2022·Journal of the American Chemical Society·Hui ChenShelley D Minteer

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Methods Mentioned

BETA
electron microscopy
deamination
NMR
PCR

Software Mentioned

Nova

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