Transfer of spontaneously hatching or hatched blastocyst yields better pregnancy rates than expanded blastocyst transfer

Journal of Human Reproductive Sciences
Natachandra M ChimoteBindu N Mehta

Abstract

Blastocyst stage embryo transfer (ET) has become routine practice in recent years. However, probably due to limitations of assisted hatching techniques, expanded blastocyst transfer (EBT) is still the preferred mode. Inexplicably, not much consideration has been given to spontaneously hatching/hatched blastocyst transfer (SHBT). This study aimed to investigate developmental potential of spontaneously hatching/hatched blastocyst against EBT in in vitro fertilization (IVF) cycles. Prospective study of 146 women undergoing their first IVF- ET cycle. On the basis of blastocyst status, women were classified into SHBT and EBT groups. Intracytoplasmic sperm injection cycles were excluded to remove male factor bias. Implantation rate (IR), clinical pregnancy rate, and live birth rate were the main outcome measures. Graph-pad Prism 5 statistical package. SHBT group showed significantly higher blastocyst formation rate (53.3 ± 17.5 vs. 43.1 ± 14.5%, P = 0.0098), top-quality blastocysts (71.8 vs. 53.7%, P = 0.0436), IR (43.6 vs. 27.9%, P = 0.0408), pregnancy rate (59.4 vs. 45.1%, P = 0.0173), and live birth rate (36.8 vs. 22.8%, P = 0.003) compared to EBT group. Multiple pregnancy rates remained comparable between the two groups. Implanta...Continue Reading

References

Jan 1, 1995·Journal of Assisted Reproduction and Genetics·M C SchieweJ P Balmaceda
Jun 9, 2001·Current Opinion in Obstetrics & Gynecology·J A Garcia-Velasco, C Simón
Oct 24, 2006·Fertility and Sterility·UNKNOWN Practice Committee of the Society for Assisted Reproductive Technology, UNKNOWN Practice Committee of the American Society for Reproductive Medicine

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Citations

Apr 23, 2016·Clinical and Experimental Reproductive Medicine·Huiqun YinYang Li
Jul 1, 2016·Clinical and Experimental Reproductive Medicine·Yong Soo HurJin Ho Lim
Feb 7, 2020·Journal of Developmental Biology·Christopher D SmallBryan D Crawford
Jan 21, 2021·Journal of Assisted Reproduction and Genetics·Romualdo SciorioSusan J Pickering
Mar 18, 2021·The Cochrane Database of Systematic Reviews·Lauren LaceyM Ahsan Akhtar
Aug 20, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liyou AnFuliang Du

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Software Mentioned

Graph
- pad prism

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