PMID: 9542156May 16, 1998Paper

Transfer of steroidal and nonsteroidal compounds across guinea pig fetal membranes

The Journal of Experimental Zoology
D E Goldhawk, R Hobkirk

Abstract

Transfer of steroidal and nonsteroidal compounds across guinea pig amnion and chorion laeve was investigated as a function of stage of gestation, tissue orientation, steroid specificity, and molecular size. Each fetal membrane was examined at early and late stages of gestation, before and after pubic symphysis relaxation. Early amnion was impermeable to macromolecules and small charged molecules while [3H]estrone and [3H]pregnenolone were transferred, the latter depending on tissue orientation and involving conjugation at the basolateral interface. After symphysis dilation, amnion transferred all substrates tested with the exception of BSA; the molecular weight cutoff was approximately 5,000. Unlike amnion, early chorion transferred both free and conjugated steroids as well as inorganic sulfate. Transfer of estrone involved conjugation and depended on tissue orientation. Transfer of [3H]estrone-sulfate, [3H]estrone-glucuronide, and [3H]pregnenolone-sulfate was similar despite selective deconjugating activity toward estrone-sulfate. Near term, chorion was impermeable to inorganic sulfate and transfer of estrone-glucuronide depended on tissue orientation, involving deconjugation in the maternal to fetal direction. At no stage of ...Continue Reading

References

May 1, 1977·The Journal of Endocrinology·J R ChallisG D Thorburn
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Mar 1, 1993·Trends in Endocrinology and Metabolism : TEM·R Hobkirk

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Citations

Apr 8, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Federico G Mariona, Lluis Cabero Roura
Jun 15, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Keisuke ItonagaSusan M Jones
Oct 21, 1998·The Journal of Steroid Biochemistry and Molecular Biology·D E Goldhawk, R Hobkirk

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