PMID: 11907519Mar 22, 2002Paper

Transfer of vitiligo after allogeneic bone marrow transplantation

Journal of the American Academy of Dermatology
Abdulmajeed AlajlanKristian-Thestrup Pedersen

Abstract

Adoptive transfer of donor immunity has been demonstrated in animals after bone marrow transplantation (BMT). In humans, several autoimmune diseases have been similarly transferred. Although BMT may, per se, be associated with a modulation of the recipient's immune system, which could trigger or even cause autoimmune diseases, both animal experiments and experience with humans show the likeliness of adoptive transfer of donor immunity to the recipient. We describe a patient with multiple myeloma in whom generalized vitiligo developed within 3 months after allogeneic BMT from his HLA-matched sister with vitiligo. We believe that a form of adoptive transfer of donor immunity to the recipient might play a role in the development of vitiligo. In spite of this, neither de novo development of vitiligo in a genetically predisposed patient nor autoimmune phenomena associated with graft-versus-host disease can be completely excluded as a contributing factor for development of vitiligo in our patient. To our knowledge, this is the first case report of transfer of vitiligo after BMT from a donor with vitiligo.

Citations

May 30, 2006·The British Journal of Dermatology·S WahieS J Meggit
Nov 27, 2008·Pediatric Transplantation·Fethi MellouliMohamed Béjaoui
Feb 12, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M OgawaH Tanabe
Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
Feb 21, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Hatice SanliOsman Ilhan
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