PMID: 12756333May 21, 2003Paper

Transfer RNA modifications that alter +1 frameshifting in general fail to affect -1 frameshifting

RNA
J UrbonaviciusGlenn R Bjork

Abstract

Using mutants (tgt, mnmA(asuE, trmU), mnmE(trmE), miaA, miaB, miaE, truA(hisT), truB) of either Escherichia coli or Salmonella enterica serovar Typhimurium and the trm5 mutant of Saccharomyces cerevisiae, we have analyzed the influence by the modified nucleosides Q34, mnm(5)s(2)U34, ms(2)io(6)A37, Psi39, Psi55, m(1)G37, and yW37 on -1 frameshifts errors at various heptameric sequences, at which at least one codon is decoded by tRNAs having these modified nucleosides. The frequency of -1 frameshifting was the same in congenic strains only differing in the allelic state of the various tRNA modification genes. In fact, in one case (deficiency of mnm(5)s(2)U34), we observed a reduced ability of the undermodified tRNA to make a -1 frameshift error. These results are in sharp contrast to earlier observations that tRNA modification prevents +1 frameshifting suggesting that the mechanisms by which -1 and +1 frameshift errors occur are different. Possible mechanisms explaining these results are discussed.

References

Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J D DinmanR B Wickner
Jan 1, 1990·Progress in Nucleic Acid Research and Molecular Biology·R B WeissR F Gesteland
Jan 1, 1987·Cold Spring Harbor Symposia on Quantitative Biology·R B WeissR F Gesteland
Apr 1, 1986·Genetics·R B Weiss, J A Gallant
May 25, 1994·Molecular & General Genetics : MGG·C Fu, J Parker
Mar 8, 1996·Journal of Molecular Biology·Z BarakJ Gallant
Dec 10, 1998·Nucleic Acids Research·J RozenskiJ A McCloskey
Mar 4, 2000·Progress in Nucleic Acid Research and Molecular Biology·P J Farabaugh
Feb 28, 2001·The EMBO Journal·G R BjörkO P Persson
Mar 23, 2002·Cell·V Ramakrishnan
Apr 12, 2002·Trends in Biochemical Sciences·Guillaume StahlPhilip J Farabaugh
Sep 21, 2002·Molecular Genetics and Genomics : MGG·J P MasucciJ Atkinson

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Citations

Jan 13, 2004·Nucleic Acids Research·Paul F Agris
Feb 14, 2006·Nucleic Acids Research·J Ross BuchanIan Stansfield
Mar 5, 2009·Microbiology and Molecular Biology Reviews : MMBR·John F Atkins, Glenn R Björk
Aug 7, 2010·Genome Biology and Evolution·Tobias WarneckeLaurence D Hurst
Sep 3, 2010·Genes & Development·Eric M Phizicky, Anita K Hopper
Sep 3, 2011·Microbiology and Molecular Biology Reviews : MMBR·Natalie VerstraetenJan Michiels
Feb 27, 2013·RNA·Irina Shepotinovskaya, Olke C Uhlenbeck
Dec 8, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Eric D Brown
Mar 3, 2004·Bioorganic Chemistry·Shaolian ZhouJames A McCloskey
Apr 16, 2010·Current Opinion in Structural Biology·Natalia DemeshkinaMarat Yusupov
Apr 2, 2008·Current Opinion in Microbiology·Estella M GustiloPaul F Agris
Dec 26, 2006·Journal of Molecular Biology·Paul F AgrisWilliam D Graham
Aug 19, 2015·Nucleic Acids Research·Hasan TükenmezAnders S Byström
Aug 9, 2011·Wiley Interdisciplinary Reviews. RNA·Yuri Motorin, Mark Helm
Nov 10, 2012·Wiley Interdisciplinary Reviews. RNA·Jane E Jackman, Juan D Alfonzo
May 29, 2004·Journal of Molecular Biology·Thomas ChristianYa-Ming Hou
Apr 15, 2004·Journal of Molecular Biology·Steven S PhelpsSimpson Joseph
May 29, 2015·Journal of Inherited Metabolic Disease·Lindsey Van HauteMichal Minczuk
Apr 30, 2015·Biochimie·Adélaïde Saint-Léger, Lluís Ribas de Pouplana
Jun 7, 2014·Frontiers in Genetics·Hiroyuki Hori
Dec 12, 2017·Bioinformatics·Anne HoffmannFabian Amman
Dec 4, 2013·Journal of Bacteriology·Karl M Thompson, Susan Gottesman
Nov 6, 2018·Protein Science : a Publication of the Protein Society·Arthur J ArcinasSquire J Booker
Apr 20, 2010·Nature Structural & Molecular Biology·Lasse B JennerMarat Yusupov
Aug 25, 2006·Journal of Biomolecular Structure & Dynamics·V R Chechetkin, V V Lobzin
May 15, 2019·Annual Review of Genomics and Human Genetics·Ashleigh E SchafferJeffery M Coller
May 22, 2017·Archives of Microbiology·Oksana KoshlaBohdan Ostash
May 1, 2014·EcoSal Plus·Glenn R Björk, Tord G Hagervall
Nov 1, 2005·EcoSal Plus·Glenn R Björk, Tord G Hagervall

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