Abstract
In recent years, actively targeted drug delivery systems have been utilized in pre-clinical studies for site-specific delivery of drugs, which reduces toxicities associated with chemotherapy. This study reports the preparation of the tumor homing ligand, transferrin (Tf) anchored methoxy-polyethylene glycol-poly(d,l-Lactide) polymeric micelles (Tf-PP). Curcumin which possess wide anti-cancer activity was loaded into the micelles. Tf-PPC with average particle size of 132.16 ± 1.37 nm and encapsulation efficiency of 88.27 ± 2.53% showed a sustained drug release. The efficacy of Tf-PPC was studied in vitro in Tf-overexpressing human cervical carcinoma (HeLa) and human hepatoma (HepG2) cells. The mouse embryo fibroblast (NIH-3T3) cells were used as control cells. Tf-PPC showed higher internalization compared to non-targeted micelles (PPC). The curcumin-mediated cytotoxicity increased significantly following Tf-PPC treatment in both the tested cell lines. In NIH-3T3 cells, Tf conjugation did not differ in comparison to the non-targeted micelles. Further, the efficiency of Tf-PPC was studied in three-dimensional (3D) HeLa tumor spheroids. The Tf-PPC was efficiently internalized by the spheroidal structures, causing higher cytotoxicit...Continue Reading
Citations
Mar 16, 2019·Nanomedicine·Preeti KumariSwati Biswas
Jan 23, 2020·Current Molecular Medicine·Ana MacedoPedro Fonte
Dec 20, 2019·Nanomedicine·Himanshu BhattSwati Biswas
Feb 13, 2020·Materials·Oana GherasimAlina Maria Holban
Apr 14, 2020·International Journal of Nanomedicine·Muhammad Muzamil KhanMuhammad Imran Khan
Nov 6, 2020·Journal of Ovarian Research·Mohammad Hossein PourhanifehHamed Mirzaei
Jan 24, 2021·Carbohydrate Polymers·Jun WangDahai Liu
Mar 4, 2021·Carbohydrate Research·Jun WangDahai Liu
Aug 20, 2019·Bioorganic & Medicinal Chemistry Letters·Surendar ChittiKondapalli Venkata Gowri Chandra Sekhar
Apr 25, 2021·Journal of Nanobiotechnology·Yu LuYuji Wang
Jan 22, 2019·International Journal of Biological Macromolecules·Qihong ZhangWeike Su
Jun 26, 2021·Nanomedicine·Swati Biswas
Jul 9, 2021·International Journal of Pharmaceutics·Yamini BobdeBalaram Ghosh
Mar 1, 2019·Molecular Pharmaceutics·Himanshu BhattSwati Biswas
Nov 26, 2020·Food Research International·Zhongqin ChenHaixia Chen