PMID: 6105517Aug 23, 1980Paper

Transferrin and transferrin receptors in carcinoma of the breast

Lancet
W P FaulkP J Stevens

Abstract

Breast tissues from 59 patients were immunohistologically studied for transferrin and transferrin receptors. None of the 8 normal breasts or 22 benign mastopathies, and only 1 of 7 fibroadenomas were reactive for transferrin, but 16 (72.7%) of 22 carcinomas were positive and parallel sections showed histopathologically that the rective areas were confined to tumour-cell membranes. That breast-tumour transferrin is probably receptor-bound in vivo was indicatd by its complete chemical removal in vitro and return to the same cells following reincubation with dilute solutions of transferrin. Similar bindig is found on certain normal or transformed cells and at the maternofetal interface of human placentae. It is suggested that this oncofetal receptor preferentially binds apotransferrin and may offer a novel approach to more specific therapy of certain breast cancers.

References

Mar 26, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·W P Faulk, G M Galbraith
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J A McIntyre, W P Faulk
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S HakomoriW W Young
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W P FaulkN Smith
Jan 1, 1978·American Journal of Clinical Pathology·B H Dorsett, H L Ioachim
Feb 25, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S R SmithersD J Hockley
Jul 1, 1974·Experimental Cell Research·D Hemmaplardh, E H Morgan
Jan 1, 1980·Cellular Immunology·G M GalbraithW P Faulk
May 1, 1980·The Journal of Clinical Investigation·T T LohE B Brown

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Citations

Aug 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M KresseW Semmler
Jan 1, 1990·Acta Neuropathologica·T OritaH Ito
Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·B VandewalleJ Lefebvre
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·F WrbaJ H Holzner
Jan 1, 1986·Breast Cancer Research and Treatment·S E TonikH H Sussman
Jul 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·K A ZirviG J Hill
Aug 1, 1992·Biological Trace Element Research·E D Weinberg
Mar 1, 1981·Biological Trace Element Research·E D Weinberg
Sep 8, 2007·Cancer Causes & Control : CCC·Geoffrey C Kabat, Thomas E Rohan
May 12, 2012·Cancer Causes & Control : CCC·Joanne KotsopoulosJan Lubinski
Nov 15, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·R TroccoliF Mannello
Jan 1, 1984·The International Journal of Biochemistry·A Hirose-KumagaiN Akamatsu
May 23, 1985·Journal of Immunological Methods·A H Lazarus, M G Baines
Mar 1, 1985·Biochimica Et Biophysica Acta·M H PennerR E Feeney
Jan 17, 1989·Biochimica Et Biophysica Acta·H M SchulmanG Shyamala
Apr 9, 1991·Biochimica Et Biophysica Acta·A BércziW P Faulk
Aug 1, 1996·Nuclear Medicine and Biology·L LangW C Eckelman
Jun 2, 2005·Journal of Autoimmunity·John A McIntyreW Page Faulk
Dec 11, 2002·European Journal of Biochemistry·Xiu-Lian DuZhong-Ming Qian
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Patrick P NgManuel L Penichet
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C A EnnsH H Sussman
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·I S Trowbridge, F Lopez
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D J FitzGeraldI Pastan
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M C Rossi, B R Zetter
Jan 1, 1983·Nutrition and Cancer·E D Weinberg
Dec 19, 2008·Critical Reviews in Food Science and Nutrition·Lígia RodriguesHelena Lindmark Månsson
Aug 21, 2012·Antioxidants & Redox Signaling·V Ashutosh Rao
Apr 21, 2004·Nuclear Medicine Communications·Tim A D SmithPaul H Walton
Apr 1, 1991·American Journal of Reproductive Immunology : AJRI·C B CoulamJ A McIntyre
Apr 1, 1991·American Journal of Reproductive Immunology : AJRI·K BarabasW P Faulk
Apr 1, 1992·American Journal of Reproductive Immunology : AJRI·J A SizenskyW P Faulk
Aug 6, 2010·Science Translational Medicine·Zandra K PinnixFrank M Torti
Dec 1, 1983·Journal of Clinical Pathology·M WellsW P Faulk
May 1, 1983·Journal of Clinical Pathology·K C GatterD Y Mason

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