PMID: 6405384May 1, 1983Paper

Transferrin as a fetal growth factor: acquisition of responsiveness related to embryonic induction

Proceedings of the National Academy of Sciences of the United States of America
P EkblomR Timpl

Abstract

Differentiation of the metanephric mesenchyme, which is triggered by an inductive tissue interaction, has been shown to proceed in a chemically defined medium containing transferrin. Here, we report that neither transferrin-depleted serum nor a chemically defined medium devoid of transferrin promote differentiation and that activity can be restored by the addition of transferrin. It thus appears that we have identified the serum factor required for kidney differentiation. Transferrin seems to affect differentiation by stimulating cell proliferation. We show by using an organ-culture model system that only mesenchymes induced to differentiate by the 24-hr tissue interaction respond to transferrin by proliferation and differentiation, whereas uninduced mesenchymes remain unresponsive. The inductor tissue used is not responsive to transferrin. Thus, the data suggest that the short-range cell-mediated tissue interaction acts by making the nephrogenic mesenchyme responsive to the long-range mediator, which is transferrin. Transferrin is suggested to be an important circulating growth factor required for proliferation during embryogenesis.

References

Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T A HamiltonH H Sussman
Jan 1, 1979·Journal of Supramolecular Structure·J W Larrick, P Cresswell
Jun 1, 1978·Nature·J Folkman, A Moscona
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K Kratochwil, P Schwartz
Sep 15, 1968·International Journal of Cancer. Journal International Du Cancer·M StokerV Waxman
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D S SalomonW R Kidwell
Aug 1, 1981·Developmental Biology·D Z Ewton, J R Florini
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E NexøR M Pratt
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·I S Trowbridge, M B Omary
Mar 15, 1981·International Journal of Cancer. Journal International Du Cancer·J E ShindelmanH H Sussman
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R SutherlandM Greaves
Aug 1, 1981·Analytical Biochemistry·S Nordling, S Aho
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A C MosesO Z Higa
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D GospodarowiczI Vlodavsky
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T H Oh, G J Markelonis
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·V R SaraL Wetterberg
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B HeubergerK Kratochwil
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P EkblomL Saxén
Jan 1, 1980·Annual Review of Biochemistry·P Aisen, I Listowsky
May 1, 1981·Developmental Biology·P EkblomL Saxén
Nov 1, 1981·Cell Differentiation·P EkblomL Saxén
Mar 15, 1980·Developmental Biology·A J D'ErcoleL E Underwood
Dec 1, 1980·Cell·D Barnes, G Sato
Apr 1, 1956·Experimental Cell Research·C GROBSTEIN
Aug 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·N K WESSELLS

❮ Previous
Next ❯

Citations

Jan 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J Davies
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M GalottoR Cancedda
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·G BeplerK Havemann
Jan 1, 1988·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·L M Sorokin, E H Morgan
Apr 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·F I NadeevIu A Chelyshev
Jan 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E D AvnerD Ellis
Nov 1, 1987·Somatic Cell and Molecular Genetics·C T TengS L Naylor
Apr 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·Y TomookaJ A McLachlan
May 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E D AvnerD Ellis
Jul 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·T TurnerG R Cunha
May 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·C R IllK G Burnett
Jun 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E J Sanders, E Cheung
Nov 17, 2009·In Vitro Cellular & Developmental Biology. Animal·Jinhyung ParkPeter C W Kim
Nov 1, 1985·Developmental Biology·D VestweberP Ekblom
Apr 1, 1985·Cell Differentiation·R L BeachB W Festoff
Nov 1, 1990·Mechanisms of Ageing and Development·F M YangB H Bowman
Jan 1, 1986·Developmental and Comparative Immunology·S F Gilbert
Jan 1, 1989·Developmental and Comparative Immunology·K KlineB G Sanders
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·H J RomijnP S Wolters
Oct 22, 1990·Molecular and Cellular Endocrinology·F R Boockfor, L K Schwarz
Dec 11, 2002·Kidney International·Indra Rani GuptaOriana H Yu
Oct 10, 1985·The New England Journal of Medicine·L R Weitkamp, B Z Schacter
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·W S MayP Cuatrecasas
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·I ParkM M Zakin
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J M HillC B Pert
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N T LeeA L Kierszenbaum
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M TaubH K Kleinman
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C R Burrow, P D Wilson
Sep 1, 1986·The Journal of Cell Biology·W Risau, P Ekblom
Jan 1, 1985·Journal of Interferon Research·L Saxén

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.