Transferrin-functionalised microemulsion co-delivery of β-elemene and celastrol for enhanced anti-lung cancer treatment and reduced systemic toxicity.

Drug Delivery and Translational Research
Qian ZhangXiufeng Cao

Abstract

In this study, we developed an intravenously injectable, transferrin-functionalised microemulsion that simultaneously carries β-elemene and celastrol (called Tf-EC-MEs) for enhanced anti-lung cancer treatment and reduced systemic toxicity. These dual-drug-loaded Tf-EC-MEs not only displayed synergistic antiproliferative effects on cultured cells in vitro, but also showed enhanced efficacy in vivo via active tumour targeting. In preparatory experiments, we found that β-elemene was capable of being used as oil phase, which enhanced drug-loading efficiency and allowed the mass ratio of β-elemene and celastrol to be optimised. In cellular studies, Tf-EC-MEs exhibited significantly improved A549 cellular uptake compared with β-elemene+celastrol (conventional combination treatment) and EC-MEs (non-active targeted treatment), demonstrating remarkable synergistic antiproliferative effects and higher rates of cell apoptosis. In A549-bearing xenograft mouse tumour models, Tf-EC-MEs exhibited enhanced antitumour activity compared to all other treatments. More importantly, Tf-EC-MEs did not cause the obvious systemic toxicity commonly found with mono-celastrol treatment. Collectively, these findings suggest that Tf-EC-MEs are a promising s...Continue Reading

References

Oct 14, 2005·Drug Development and Industrial Pharmacy·Yanzhi WangDianzhou Bi
Jan 20, 2011·Drug Development and Industrial Pharmacy·Chan-Juan HuDa-Wei Chen
May 25, 2011·ACS Nano·Erin Lavik, Horst von Recum
Nov 26, 2013·Colloids and Surfaces. B, Biointerfaces·Dong LiZhongwei Gu
Jun 5, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Patricia S NielsenAnne M B Jylling
Sep 11, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jianying LiYili Wang
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fangfang WangLi Zhu
Jan 9, 2015·Journal of Medicinal Food·Atallah F AhmedSyed Rafatullah
Jul 19, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emma TaylorPeter Mollee
Aug 1, 2015·Journal of the American Veterinary Medical Association·Kristin M WendelburgJohn Berg
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Jia-Ying FangKun Lin
Sep 4, 2015·Cancer·Qun-Ying HongUNKNOWN Lung Cancer Group of Chinese Thoracic Society; Chinese Alliance Against Lung Cancer
Sep 12, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A C R K BosV E P P Lemmens
Aug 9, 2016·International Journal of Oncology·Su-Wei XuVincent Kam Wai Wong
Jul 4, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ying LiuLiang Feng
Nov 14, 2017·Bioconjugate Chemistry·Manankumar A ShahThomas P Quinn

❮ Previous
Next ❯

Citations

Dec 29, 2020·Frontiers in Pharmacology·Jinfeng ShiChaomei Fu
Mar 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi ChenWan Liao
Jun 29, 2021·Frontiers in Pharmacology·Pushkaraj Rajendra WaghJeffrey Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
infrared spectroscopy
dynamic light scattering
transmission electron microscopy
circular dichroism
flow cytometry
xenograft

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.