PMID: 9438535Jan 23, 1998Paper

Transferrin isoform distribution: gender and alcohol consumption

Alcoholism, Clinical and Experimental Research
O MårtenssonP Sillanaukee

Abstract

Transferrin (Tf) has different isoforms based on the degree of sialylation of its two N-linked oligosaccharide chains. The least sialylated isoforms of Tf; with 0 (asialo Tf), 1 (monosialo Tf), and 2 (disialo Tf) sialic acids are referred to as carbohydrate-deficient transferrin (CDT). CDT has been reported to be a specific and sensitive marker for the detection and monitoring of alcohol abuse. However, the possible differences between the three CDT isoforms in males and females relative to alcohol consumption has not been known. The present study included 82 males (M) and 43 females (F) with well documented drinking habits. The Tf isoforms were separated by FPLC and measured by RIA in the collected fractions, as well as by a commercially available method (CDTect RIA). The results were expressed as relative values and absolute values. Female low consumers compared to male low consumers had higher levels of asialo Tf (p < 0.01) and monosialo Tf (p < 0.01), but not of disialo Tf or sum of asialo, monosialo, and disialo Tf. Male high consumers and chronic consumers compared to male low consumers had 53% and 219% higher levels of asialo Tf, 4% and 28% higher monosialo Tf, 57% and 148% higher disialo Tf, and 48% and 134% higher sum ...Continue Reading

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Citations

Jul 1, 2004·Indian Journal of Clinical Biochemistry : IJCB·Subir Kumar Das, D M Vasudevan
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·John R PetersenDeborah A Payne
Jan 30, 2003·Clinical Biochemistry·Janine Denis Cook
Nov 17, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·M Lönnberg, J Carlsson
Apr 1, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·F CrivellenteF Tagliaro
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·V Sanz-NebotJ Barbosa
Jun 19, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Klaus Golka, Andreas Wiese
Jun 15, 2011·Human Molecular Genetics·Zoltán KutalikJohn B Whitfield
Jun 3, 2014·BMC Gastroenterology·Kevin J FaganElizabeth E Powell
Apr 19, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Denis GallotVincent Sapin
Feb 27, 2004·Addiction·Tim Neumann, Claudia Spies
Mar 15, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Agnese VeronesiElisabetta Cariani
May 8, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·V WestphalH H Freeze
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·P SillanaukeeK Seppä
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·P SillanaukeeR Z Litten
Apr 19, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Jan-Olof JeppssonUNKNOWN International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardization of Carbohydrate-defi
Dec 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Cas WeykampUNKNOWN IFCC Working Group on Standardization of Carbohydrate-Deficient Transferrin (WG-CDT)

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