Transferrin receptor 1 overexpression is associated with tumour de-differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma

Histopathology
Makiko AdachiShinichi Aishima

Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. An excess of iron in liver tissue causes oxidative stress, leading to hepatocellular carcinogenesis. Iron metabolism, which is regulated by a complex mechanism, is important for cancer cell survival. The aim of this study is to clarify the role of iron regulatory protein in the progression of HCC and in patient outcome. We first investigated the mRNA level of iron metabolism-related genes, including hepcidin, ferroportin 1 (FPN-1) and transferrin receptor (TFR)-1/2. TFR-1/2 protein expression was then evaluated in surgical specimens from 210 cases using immunohistochemistry, and we compared clinicopathological factors with TFR-1/2 expression. The mRNA expression levels of TFR-1 were significantly increased in HCC tissues compared with adjacent non-cancerous tissues (P = 0.0013), but there were no differences in other genes. High expression of TFR-1 in HCC was associated with the absence of alcohol abuse (P = 0.0467), liver cirrhosis (P < 0.0001), higher alpha-fetoprotein (AFP; P < 0.0001), smaller tumour size (P = 0.0022), poor histological differentiation (P < 0.0001) and morphological features (P < 0.0001). In contrast, high expression o...Continue Reading

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Citations

Mar 28, 2020·International Journal of Molecular Sciences·Stefania ForcinitiLuigi Laghi
Jan 24, 2021·Advanced Drug Delivery Reviews·Renjie LiuGregory A Hudalla
Mar 9, 2021·Frontiers in Immunology·Wei Liang, Napoleone Ferrara
Apr 6, 2021·Frontiers in Immunology·Pierre V CandelariaTracy R Daniels-Wells
May 1, 2021·International Journal of Molecular Sciences·Rossana PaganoniMaja Vujic Spasic
May 14, 2021·Journal of Drug Targeting·Qin OuyangQubo Zhu
Jun 19, 2021·Japanese Journal of Clinical Oncology·Kenei FurukawaToru Ikegami

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