Abstract
The urinary loss of transferrin is sufficient to reduce plasma transferrin concentrations in the nephrotic syndrome. Hypotransferrinemia may lead to iron loss and microcytic anemia. The mechanism responsible for the hypotransferrinemia in the nephrotic syndrome is, however, unknown. In the present study, synthesis rate of transferrin was measured in vivo in nephrotic patients (n = 7) compared with control subjects (n = 6) using L-[1-(13)C]-valine. Plasma transferrin and iron concentration in the patients were significantly lower than in control subjects (transferrin, 1.39 +/- 0.08 versus 2.57 +/- 0.11 g/L, P < 0.0001; iron, 10.2 +/- 0.8 versus 21.1 +/- 4.5 micromol/L, P = 0.02). Furthermore, albuminuria correlated with transferrinuria (r(2) = 0.901, P = 0.001). The absolute synthesis rate of transferrin was increased in the patients (10.0 +/- 1.1 versus 7.4 +/- 0.7 mg/kg per d, P = 0.07), although this value failed to achieve significance. C-reactive protein, plasma iron, and proteinuria did not correlate with transferrin synthesis. In contrast, transferrin synthesis correlated with albumin synthesis (r(2) = 0.648, P = 0.03; n = 7). The present study indicates that increased transferrin synthesis occurs in nephrotic patients bu...Continue Reading
References
Jan 1, 1976·American Journal of Clinical Pathology·D E HancockP L Wolf
Nov 1, 1991·Kidney International·R L HowardA C Alfrey
Jan 1, 1991·The American Journal of the Medical Sciences·H L Bonkovsky
Aug 1, 1991·American Journal of Clinical Pathology·R L HamillB A Cook
Apr 1, 1987·Brain Research Bulletin·B BlochA Kahn
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R L IdzerdaG S McKnight
Nov 1, 1972·The Biochemical Journal·K N JeejeebhoyU Sodtke
Mar 1, 1972·The Biochemical Journal·K N JeejeebhoyU Sodtke
Jan 1, 1965·Advances in Protein Chemistry·R L Hill
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·H JensenM Yssing
Nov 1, 1984·Clinical Immunology and Immunopathology·B L WarshawS C DiRusso
Nov 1, 1984·Infection and Immunity·D L BeaumierB E Holbein
Apr 1, 1981·Biomedical Mass Spectrometry·F RocchiccioliP Cartier
May 1, 1994·Kidney International·X Sun, G A Kaysen
Feb 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M A CooperA C Alfrey
Apr 1, 1995·Kidney International·G A KaysenH al-Bander
Jan 1, 1993·American Journal of Nephrology·G A Kaysen
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A C Alfrey
May 1, 1996·The Journal of Nutrition·F JahoorM Frazer
Aug 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R T GansevoortP E de Jong
May 15, 1997·The Journal of Clinical Investigation·B J MaroniK Tom
Aug 1, 1997·The Journal of Nutrition·J F MorleseF Jahoor
Feb 7, 1998·Kidney International·M G de Sain-van der VeldenH A Koomans
Aug 6, 1998·Journal of Mass Spectrometry : JMS·D J ReijngoudF Stellaard
Dec 23, 1999·The New England Journal of Medicine·N C Andrews
Jan 14, 2000·Journal of Clinical Laboratory Analysis·R F RitchieW Y Craig
Feb 8, 2000·Intensive Care Medicine·M OppertK U Eckardt
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M G de Sain-Van Der VeldenG A Kaysen
Nov 10, 1956·Nature·J R DEBRO, A KORNER
Dec 1, 1961·The Journal of Clinical Investigation·J H KATZ
Citations
Apr 30, 2021·Frontiers in Medicine·Ewa WlazloYogesh Scindia
Jan 16, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Pietro Castellino, Alessandro Cataliotti
Dec 21, 2002·Clinical Biochemistry·Berthil H C M T PrinsenMonique G M de Sain-van der Velden
Dec 11, 2002·Kidney International·George A KaysenUNKNOWN HEMO Group
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·P H BisschopJ A Romijn
Sep 13, 2003·Kidney International·Berthil H C M T PrinsenMonique G M De Sain-Van Der Velden
Feb 12, 2004·Kidney International·Berthil H C M T PrinsenMonique G M de Sain-van der Velden
Jun 30, 2004·Isotopes in Environmental and Health Studies·Marianne Wigger, Klaus Wutzke
Aug 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Berthil H C M T Prinsen, Monique G M de Sain-van der Velden
Jul 3, 2021·Cells·Jasmin I MaierChristoph Schell
Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nina MährKarl Lhotta
Jul 11, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Edwin Patino, Oleh Akchurin
Jul 7, 2021·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S SreekanthK Tiewsoh
Dec 2, 2008·Biochimica Et Biophysica Acta·Craig P Smith, Frank Thévenod
Mar 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Angel A Soler-GarcíaPatricio E Ray