PMID: 109127May 25, 1979

Transfomration of arachidonic acid into 12-hydroxy-5,8,10,14-eicosatetraenoic acid by mouse peritoneal macrophages

Biochimica Et Biophysica Acta
M RigaudJ C Breton

Abstract

Mouse peritoneal macrophages were incubated at 37 degrees C for 30 min with arachidonic acid (all-cis-5,8,11,14-eicosatetraenoic acid). Oxygenation of arachidonic acid in mouse peritoneal macrophages occurs by two major pathways: fatty acid cyclooxygenase and lipoxygenase. The major metabolite of the latter is 12-hydroxy-5,8,10,14-eicosatetraenoic acid which was identified by gas liquid chromatography on high resolution glass capillary column and mass spectrometry.

References

Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson

Citations

Apr 1, 1981·Archives Internationales De Pharmacodynamie Et De Thérapie·M ClaeysD H Nugteren
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·H Rabinovitch-ChableM Rigaud
Oct 1, 1995·Journal of Lipid Mediators and Cell Signalling·T Yoshimoto, S Yamamoto
Jun 1, 1982·The Journal of Experimental Medicine·N A PawlowskiZ A Cohn
Mar 15, 1986·Biochemical Pharmacology·J R BeetensF De Clerck
Jul 1, 1982·Clinical and Experimental Dermatology·R D Camp
Apr 1, 1989·Journal of Veterinary Internal Medicine·B Hansen

Related Concepts

Metazoa
Eicosatetraenoic Acids
Peritoneal Fluid (Body Substance)
Chromatography, Gas-Liquid
Lipoxygenase-2
Macrophage
Mass Spectrometry
Mouse, Swiss

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