Transformation and Cytotoxicity of Surface-Modified Silver Nanoparticles Undergoing Long-Term Aging

Nanomaterials
Chengfang PangBin Zhao

Abstract

Silver nanoparticles (AgNPs) are constituents of many consumer products, but the future of their production depends on ensuring safety. The stability of AgNPs in various physiological solutions and aging in storage may affect the accuracy of predicted nanoparticle toxicity. The goal of this study was to simulate the transformation of AgNPs in different media representatives to the life cycle in the environment and to identify their toxicity to Hepa1c1c7 cells in a long-term aging process. AgNPs coated with citrate, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and branched polyethyleneimine (BPEI) were studied. Our results show that the exposure media had a significant impact on the transformation of AgNPs. Citrate-coated AgNPs showed significant aggregation in phosphate-buffered saline. The aging of AgNPs in optimal storage showed that the charge-stabilized particles (citrate) were more unstable, with significant aggregation and shape changes, than sterically stabilized particles (PEG AgNPs, PVP AgNPs). The BPEI AgNPs showed the highest dissolution of AgNPs, which induced significantly increased toxicity to Hepa1c1c7 cells. Overall, our findings showed that storage and media of AgNPs influenced the transformation of A...Continue Reading

References

Jan 24, 2007·Journal of Colloid and Interface Science·Jun YangHeng-Phon Too
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin LundqvistKenneth A Dawson
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Feb 24, 2010·Environmental Science & Technology·Jingyu Liu, Robert H Hurt
Apr 7, 2011·Environmental Science & Technology·Ralf KaegiHansruedi Siegrist
Mar 22, 2012·Environmental Science & Technology·Mila TejamayaJamie R Lead
May 15, 2012·The Science of the Total Environment·Amro M El BadawyThabet Tolaymat
Jul 24, 2013·Antimicrobial Agents and Chemotherapy·Divya Prakash GnanadhasDipshikha Chakravortty
Sep 17, 2013·PloS One·Jonathan H ShannahanFrank A Witzmann
Sep 24, 2013·Nature Nanotechnology·Stefan TenzerRoland H Stauber
Jan 11, 2014·Advances in Colloid and Interface Science·Virender K SharmaJorge L Gardea-Torresdey
Mar 16, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kathy C NguyenAzam F Tayabali
Mar 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·K LozaM Epple

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Citations

Aug 17, 2021·The Science of the Total Environment·Yanping ChengGeyu Liang

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Methods Mentioned

BETA
Assay
transmission electron microscopy
dynamic light scattering

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