Abstract
A recurrent chromosomal abnormality associated with a subset of papillary renal cell carcinomas is t(X;1)(p11;q21). This translocation leads to the formation of two fusion genes, TFE3PRCC and the reciprocal product PRCCTFE3. Both fusion genes are expressed in t(X;1)-positive renal cell carcinomas and contain major parts of the coding regions of the parental transcription factor PRCC and TFE3 genes, respectively. To find out whether these fusion genes possess transforming capacity, we transfected NIH3T3 and rat-1 cells with the fusion products, either separately or combined. When using soft agar assays, we observed colony formation in all cases. NIH3T3 cells transfected with PRCCTFE3 or PRCCTFE3 together with TFE3PRCC yielded the highest colony forming capacities. Examination of other characteristics associated with malignant transformation, i.e., growth under low-serum conditions and formation of tumors in athymic nude mice, revealed that cells transfected with PRCCTFE3 exhibited all these transformation-associated characteristics. Upon transfection of the fusion products into conditionally immortalized kidney cells, derived from the proximal tubules of an H-2Kb-tsA58 transgenic mouse, and consecutive incubation under non-permi...Continue Reading
References
Feb 1, 1992·Molecular and Cellular Biology·C RomanK Calame
Jun 1, 1991·Genes & Development·H Beckmann, T Kadesch
Aug 1, 1988·The Journal of Pathology·W ThoenesS Werner
Mar 15, 1986·Cancer Genetics and Cytogenetics·B de JongJ W Oosterhuis
Jan 1, 1988·Cytogenetics and Cell Genetics·G KovacsT Papp
May 1, 1986·Pathology, Research and Practice·W ThoenesH J Rumpelt
Jun 1, 1980·European Journal of Biochemistry·C Auffray, F Rougeon
Aug 1, 1995·Cancer Genetics and Cytogenetics·M J Hernandez-MartíA Paradís-Alós
May 1, 1995·Cancer Genetics and Cytogenetics·V TonkG E Tomlinson
Nov 10, 1994·Nature·T H Rabbitts
Sep 9, 1993·International Journal of Cancer. Journal International Du Cancer·E van den BergB de Jong
Jan 1, 1993·Cancer Genetics and Cytogenetics·A M MeloniA A Sandberg
Sep 1, 1995·Genes, Chromosomes & Cancer·T DijkhuizenB de Jong
Oct 1, 1995·Lupus·C OrellanaJ Muñoz-Gomez
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·C S ZentG Nucifora
Jul 1, 1996·Human Genetics·M A WetermanA Geurts van Kessel
Feb 1, 1996·Seminars in Cancer Biology·P H Sorensen, T J Triche
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A WetermanA Geurts van Kessel
Dec 11, 1997·Oncogene·J ClarkC S Cooper
Apr 16, 1998·European Journal of Endocrinology·M De RosaG Lombardi
Sep 2, 1998·Medical and Pediatric Oncology·M D CarcaoS Baruchel
Apr 13, 1999·Cancer Genetics and Cytogenetics·C PérotJ Couturier
Sep 15, 1999·Cancer Genetics and Cytogenetics·F DésanglesM Arborio
Oct 19, 1999·Oncogene·A D ThompsonC T Denny
Jan 25, 2000·Oncogene·M J WetermanA G van Kessel
Mar 29, 1996·Breast Cancer : the Journal of the Japanese Breast Cancer Society·R Abe
Citations
Oct 22, 2004·Urological Research·M A Noordzij, G H Mickisch
Dec 3, 2002·The American Journal of Surgical Pathology·Pedram ArganiMarc Ladanyi
Jan 8, 2008·Journal of Pediatric Hematology/oncology·David T VisticaRobert H Shoemaker
May 31, 2006·American Journal of Nephrology·Andreas A SkolarikosCharalambos Deliveliotis
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·M A WetermanA G van Kessel
Jul 23, 2014·Nature Reviews. Urology·Eric C KauffmanW Marston Linehan
Nov 15, 2007·Cytogenetic and Genome Research·K MedendorpR P Kuiper
May 9, 2009·Experimental Cell Research·Klaas MedendorpAd Geurts van Kessel
Mar 25, 2008·Pathology, Research and Practice·J Müller-HöckerA Jung
Jan 13, 2015·Future Oncology·Diana Silva Fernandes, José Manuel Lopes
Apr 11, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Shiv Prakash VermaParimal Das
Aug 25, 2015·Frontiers in Physiology·Frank Park
Dec 1, 2004·Annual Review of Genetics·Eiríkur SteingrímssonNancy A Jenkins
Mar 13, 2001·Oncogene·M LadanyiJ Bridge
Apr 21, 2001·Oncogene·Y M SkalskyC S Cooper
Jul 13, 2006·Oncogene·M Mathur, H H Samuels
Aug 2, 2006·American Journal of Clinical Pathology·Raveena RamphalBo-Yee Ngan
Jan 30, 2015·The Journal of Pharmacology and Experimental Therapeutics·Frank Park
Mar 10, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xiaoqin YinDongmei Li
Apr 14, 2021·Oncogene·Ru FangQiu Rao
Jul 6, 2021·Biochemical and Biophysical Research Communications·Guang YangJing Wang
Sep 6, 2005·Annales de pathologie·Eacute Va CompératAnnick Vieillefond