Transformation of a Nonfunctional Paraganglioma With I-123 MIBG Scintigraphy Correlation: A Case Report.

Medicine
Eric A DavalosJohn Shim

Abstract

A 35-year-old woman presenting with abdominal pain was found to have mildly elevated catecholamine levels and a retroperitoneal mass. The patient underwent a negative I-123 MIBG scintigraphy scan and a nondiagnostic fine needle aspiration. Eleven years later the patient presented with a hypertensive emergency and markedly elevated catecholamine levels. A subsequent I-123 MIBG scintigraphy scan showed intense uptake corresponding to the previously seen retroperitoneal mass. The patient underwent surgical resection and pathology confirmed the presence of a paraganglioma. A paraganglioma is an extra-adrenal pheochromocytoma that contains chromaffin cells and is thus capable of producing catecholamines. I-123 metaiodobenzylguanidine (MIBG) scintigraphy has become the imaging study of choice for paragangliomas and has a sensitivity of ∼77% to 100% in detecting functional paragangliomas. This case demonstrates scintigraphic correlation of the functional transformation of a nonfunctional paraganglioma in a time span of ∼10 years. Although there are previously published case reports of scintigraphic positive, nonfunctional paragangliomas and scintigraphic negative chromaffin cell tumors, there has been no prior documented case of scint...Continue Reading

References

Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ioannis Ilias, Karel Pacak
Jul 14, 2004·European Journal of Endocrinology·Gregory KaltsasAshley B Grossman
Sep 13, 2007·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Charles M IntenzoEdith P Mitchell
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Jun 6, 2015·Endocrine-related Cancer·Frédéric CastinettiDavid Taieb

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