Transformation of a Spatial Map across the Hippocampal-Lateral Septal Circuit

Neuron
David Tingley, Gyorgy Buzsaki

Abstract

The hippocampus constructs a map of the environment. How this "cognitive map" is utilized by other brain regions to guide behavior remains unexplored. To examine how neuronal firing patterns in the hippocampus are transmitted and transformed, we recorded neurons in its principal subcortical target, the lateral septum (LS). We observed that LS neurons carry reliable spatial information in the phase of action potentials, relative to hippocampal theta oscillations, while the firing rates of LS neurons remained uninformative. Furthermore, this spatial phase code had an anatomical microstructure within the LS and was bound to the hippocampal spatial code by synchronous gamma frequency cell assemblies. Using a data-driven model, we show that rate-independent spatial tuning arises through the dynamic weighting of CA1 and CA3 cell assemblies. Our findings demonstrate that transformation of the hippocampal spatial map depends on higher-order theta-dependent neuronal sequences. VIDEO ABSTRACT.

Citations

Jul 14, 2019·Hippocampus·Kevin A BoldingRobert U Muller
Apr 9, 2020·Brain Connectivity·Hamid Soltani ZangbarParviz Shahabi
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Tingley, Adrien Peyrache
Sep 8, 2020·ELife·Estefania P AzevedoSarah A Stern
Jun 30, 2019·Journal of Cognitive Neuroscience·Holger DannenbergMichael E Hasselmo
Jan 27, 2019·PLoS Computational Biology·Joseph D MonacoKechen Zhang
Dec 5, 2019·Physiology·Lisa MarshallThien Thanh Dang-Vu
Dec 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Kathryn McClainGyörgy Buzsáki
Feb 11, 2020·Current Pharmaceutical Biotechnology·Zhaohu YuanHuikuan Yang
Jan 5, 2021·Neuroinformatics·Espen HagenAlexander J Stasik
Sep 24, 2019·Current Biology : CB·Hannah S Wirtshafter, Matthew A Wilson
Sep 30, 2018·Trends in Cognitive Sciences·György Buzsáki, David Tingley
Aug 9, 2020·Neuron·Travis D GoodeThomas J McHugh
Aug 13, 2021·Nature·David TingleyGyörgy Buzsáki

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