Transformation of catalytic characteristics of cerebral monoamine oxidases in experimental posttraumatic stress disorders

Bulletin of Experimental Biology and Medicine
L I KolesnikovaL I Krupitskaya

Abstract

We studied the contribution of the transformation of the catalytic properties of cerebral monoamine oxidase in the development of behavioral disorders during stress. Monoamine oxidase activities and catalytic characteristics, LPO intensity, and oxidative modification of proteins in suspension of the brain mitochondria were evaluated over the course of experimental posttraumatic stress disorder. The detected shifts were comparable with the results of neuroethologic testing. The development of behavioral disorders presented by low exploratory activity and high anxiety was associated with transformation of catalytic characteristics of cerebral monoamine oxidases, associated with the development of oxidative stress with predominant intensification of metal-catalyzed protein oxidation.

References

Oct 30, 2001·Behavioural Brain Research·C Belzung, G Griebel
Jul 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hagit CohenGal Richter-Levin
Mar 2, 2011·Journal of Neural Transmission·Jean C ShihKevin Chen

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Citations

Jul 6, 2017·Cellular and Molecular Neurobiology·Svetlana S LazukoVadim E Tseilikman

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