Transformation of cell cultures as a parameter for detecting the potential carcinogenicity of antischistosomal drugs

Journal of Toxicology and Environmental Health
F M Hetrick, W L Kos

Abstract

Several antischistosomal drugs and their metabolites were found to transform rat embryo cell cultures persistently infected with the Rauscher leukemia virus. The transformed cells produced fibrosarcomas when implanted into newborn rats. Cell cultures treated with either virus or chemical alone were not transformed nor were they invasive in rats. The advantages of early screening of developmental drugs in cell culture systems are discussed.

References

Sep 1, 1973·Journal of the National Cancer Institute·A E FreemanR J Huebner

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Citations

Nov 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J SimonsR J Ruane
May 1, 1991·Perception & Psychophysics·R L Savoy, J D Gabrieli

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