Transformation of double-hit follicular lymphoma to plasmablastic lymphoma: a partial role of MYC gene rearrangement

Journal of Clinical and Experimental Hematopathology : JCEH
Mikiko IseMakiko Itami

Abstract

Follicular lymphoma (FL) is genetically characterized by BCL2/IGH translocation. Some FL cases histologically transform to high-grade lymphoma, and the majority of cases transform to diffuse large B-cell lymphoma. We report herein an unusual FL case that transformed to plasmablastic lymphoma (PBL) with MYC gene rearrangement as early as 12 months after FL diagnosis. IGH/MYC translocation, the most common cytogenetic abnormality seen in de novo PBL, was also detected in the transformed tumor (double-hit lymphoma). The patient became resistant to chemotherapy and died 4 months after transformation. We speculate that the "second hit" of MYC rearrangement played a crucial role in PBL transformation (PBL-T) in this case. Highly specific three-color FISH analysis demonstrated the presence of BCL2/IGH/MYC triple fusion signals on a single chromosome as we expected, but BCL2/IGH and IGH/MYC fusion signals also coexisted in a single nucleus. The PBL-T tumor was genetically heterogeneous, despite being histologically quite homogeneous PBL. Surprisingly, three-color FISH analysis revealed that the preceding FL tumor was also genetically heterogeneous, simultaneously harboring BCL2/IGH, IGH/MYC and BCL2/IGH/MYC fusion signals (i.e. double-...Continue Reading

References

Oct 22, 2010·The American Journal of Surgical Pathology·Alexandra ValeraElías Campo
Nov 23, 2010·American Journal of Clinical Pathology·Ihsane OuansafiWayne Tam
Jan 4, 2013·The American Journal of Surgical Pathology·Daniel MartinezAntonio Martinez
Jan 7, 2014·Cell Reports·Laura PasqualucciRiccardo Dalla-Favera
Nov 8, 2015·The Lancet Oncology·Clémentine SarkozyBertrand Coiffier
Jun 11, 2017·Blood·Jonathan W Friedberg
Jul 18, 2017·Clinical Lymphoma, Myeloma & Leukemia·Chadi Nabhan, Anthony R Mato

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Citations

Nov 19, 2019·Pathology·Chi Young Ok, L Jeffrey Medeiros

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Methods Mentioned

BETA
biopsy
electrophoresis

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