Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-γ production

PLoS Neglected Tropical Diseases
Bilin DongLiuqing Chen

Abstract

Fonsecaea pedrosoi (F. pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection. Experimental studies in murine models have shown that the absence of CD4+ T cells impairs host defense against F. pedrosoi infection. Clinical research has also suggested that a relatively low level of the Th1 cytokine INF-γ and inefficient T cell proliferation are simultaneously present in patients with severe chromoblastomycosis upon in vitro stimulation with ChromoAg, an antigen prepared from F. pedrosoi. In the present study, we show that in mice intraperitoneally infected with F. pedrosoi-spores, -hyphae or in vitro-induced sclerotic cells respectively, the transformation of this causative agent into sclerotic cells contributes to a compromised Th1 cytokine production in the earlier stage of infection with impaired generation of neutrophil reactive oxygen species (ROS) and pan-inhibition of Th1/Th2/Th17 cytokine production with disseminated infection in the later stage by using a CBA murine Th1/Th2/Th17 cytokine kit. In addition, we have further demonstrated that intraperitoneal admin...Continue Reading

References

Jan 20, 1995·The Journal of Biological Chemistry·R KollárE Cabib
Aug 2, 2000·Trends in Microbiology·H de NobelF M Klis
Feb 24, 2001·Medical Mycology·G S De HoogF Yegres
Jun 13, 2003·Molecular Biology of the Cell·Martin SchmidtEnrico Cabib
Aug 2, 2003·International Journal of Dermatology·Marília M OgawaJane Tomimori-Yamashita
Apr 26, 2005·Microbes and Infection·Viviane Mazo Fávero GimenesSandro Rogério Almeida
Aug 10, 2006·Mycopathologia·Viviane Mazo Fávero GimenesSandro Rogério Almeida
Aug 24, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shaun M Bowman, Stephen J Free
Nov 7, 2006·Scandinavian Journal of Immunology·M da Gloria Teixeira de SousaS R Almeida
Jan 19, 2007·European Journal of Immunology·Adam D KennedyFrank R DeLeo
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carla A Da SilvaJack A Elias
May 5, 2009·The Journal of Allergy and Clinical Immunology·Jennifer LoutenRene de Waal Malefyt
Jul 7, 2009·Clinical and Experimental Dermatology·M Ameen
Mar 23, 2010·Tropical Doctor·Mahreen Ameen
Apr 15, 2010·Marine Drugs·Riccardo A A Muzzarelli
Feb 2, 2011·PLoS Pathogens·Sonja I GringhuisTeunis B H Geijtenbeek
Mar 12, 2011·Nature Reviews. Immunology·Luigina Romani
Apr 1, 2011·Medical Mycology·Adawiyah JamilSuganthi Thevarajah
Dec 22, 2011·International Journal of Microbiology·Karina Vega, Markus Kalkum
Feb 20, 2013·Advances in Genetics·Stephen J Free
Aug 21, 2013·Nature Reviews. Microbiology·Enrico Cabib, Javier Arroyo
Feb 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Conceição M P S AzevedoMaria A Resende-Stoianoff
Jun 5, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marina Lara de CarliJoão Adolfo Costa Hanemann
Nov 20, 2016·Clinical Microbiology Reviews·Flavio Queiroz-TellesThomas J Walsh

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Citations

Jun 12, 2020·The American Journal of Tropical Medicine and Hygiene·Bilin DongDongsheng Li
Jul 19, 2019·Mycopathologia·Gabriela X SchneiderVânia A Vicente
Aug 28, 2020·Frontiers in Genetics·Amanda BombassaroVânia A Vicente
Nov 17, 2020·Frontiers in Immunology·Leandro Carvalho Dantas BredaSandro Rogério de Almeida
Jun 3, 2021·International Journal of Molecular Sciences·Yu SawadaMotonobu Nakamura

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Datasets Mentioned

BETA
GQ420654.1

Methods Mentioned

BETA
scraping
Assay
FCS
flow cytometry

Software Mentioned

GraphPad Prism
FCAP Array

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