PMID: 6986302Feb 1, 1980Paper

Transformation of glicentin-containing L-cells into glucagon-containing cells by enzymatic digestion

Diabetes
M Ravazzola, L Orci

Abstract

Exposure of sections of ileal mucosa to enzymatic digestion with trypsin and carboxypeptidase B reveals a population of immunofluorescent cells after incubation with a specific C-terminally directed antiglucagon serum. These cells, unreactive before enzyme treatment, were identified as L-cells by their immunoreactivity to antiglicentin serum and to cross-reacting (N-terminal) antiglucagon sera. The presence in the L-cells of antigenic sites characteristic of the glucagon-containing cells (A-cells) emphasizes the close relationships between these two cell types, and it further supports the hypothesis of glicentin as a glucagon precursor.

Citations

Jun 18, 1981·The New England Journal of Medicine·R H Unger, L Orci
Dec 1, 1981·Gut·G B Irvine, R F Murphy
Oct 12, 1981·Life Sciences·M TominagaH Sasaki
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·A J FourieR Hickman
Aug 1, 1991·The Journal of Comparative Neurology·G Y LázárI Merchenthaler
Jan 1, 1985·Progress in Histochemistry and Cytochemistry·J A Litwin
Mar 1, 1982·Journal of Endocrinological Investigation·G TamburranoD Andreani

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.