Transformation of Helicobacter pylori into Coccoid Forms as a Challenge for Research Determining Activity of Antimicrobial Substances

Pathogens
Paweł Krzyżek, Rossella Grande

Abstract

Morphological variability is one of the phenotypic features related to adaptation of microorganisms to stressful environmental conditions and increased tolerance to antimicrobial substances. Helicobacter pylori, a gastric mucosal pathogen, is characterized by a high heterogeneity and an ability to transform from a spiral to a coccoid form. The presence of the coccoid form is associated with the capacity to avoid immune system detection and to promote therapeutic failures. For this reason, it seems that the investigation for new, alternative methods combating H. pylori should include research of coccoid forms of this pathogen. The current review aimed at collecting information about the activity of antibacterial substances against H. pylori in the context of the morphological variability of this bacterium. The collected data was discussed in terms of the type of substances used, applied research techniques, and interpretation of results. The review was extended by a polemic on the limitations in determining the viability of coccoid H. pylori forms. Finally, recommendations which can help in future research aiming to find new compounds with a potential to eradicate H. pylori have been formulated.

References

Oct 1, 1994·American Journal of Clinical Pathology·W Y ChanC S Ng
Feb 1, 1995·The Journal of Infectious Diseases·K A EatonS Krakowka
Dec 1, 1993·Journal of General Microbiology·G BodeP Malfertheiner
Dec 1, 1993·Epidemiology and Infection·G BodeP Malfertheiner
Mar 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M SörbergL E Nilsson
May 1, 1997·Clinical and Diagnostic Laboratory Immunology·S NarikawaY Mizushima
Sep 1, 1997·Infection and Immunity·J G KustersC M Vandenbroucke-Grauls
Aug 1, 1997·Journal of Medical Microbiology·X WangT Wadström
Dec 16, 1998·FEMS Immunology and Medical Microbiology·H J MonsteinJ Jonasson
Jun 10, 2000·Journal of Medical Microbiology·M ShiraiT Nakazawa
Jun 26, 2001·Helicobacter·H J MonsteinJ Jonasson
Jan 5, 2002·Applied and Environmental Microbiology·Hans-Olof NilssonTorkel Wadström
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Bee Ling NgBow Ho
Apr 15, 2004·Free Radical Biology & Medicine·Ah-Mee ParkMasayasu Inoue
Dec 24, 2005·Annals of Clinical Microbiology and Antimicrobials·Shaik Mahaboob AliNiyaz Ahmed
Jun 13, 2006·Experimental and Molecular Pathology·Manoucher ShahamatMehdi Alem
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Osamu KamodaShigeru Kamiya
Apr 3, 2007·Applied and Environmental Microbiology·N F AzevedoM J Vieira
Jan 16, 2009·Journal of Gastroenterology and Hepatology·Masashi MatsushimaTetsuya Mine
Dec 15, 2010·Journal of Applied Microbiology·R GrandeL Cellini
Aug 6, 2011·Microbial Cell Factories·Lucia Achbergerová, Jozef Nahálka
May 30, 2012·Journal of Applied Microbiology·R GrandeL Cellini
Jun 13, 2012·Antimicrobial Agents and Chemotherapy·Suchandra GoswamiPratap K Das
Jul 26, 2012·Molecular Pharmaceutics·Marygorret ObonyoLiangfang Zhang
Oct 10, 2013·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Hala El-ZimaityAmir Samani
Oct 31, 2013·International Journal of Environmental Research and Public Health·Sun Hee MoonHyun-Dong Paik
May 17, 2014·World Journal of Gastroenterology : WJG·David Y Graham
Aug 26, 2014·Jundishapur Journal of Microbiology·Jamshid FaghriHajieh Ghasemian Safaei
Oct 4, 2014·World Journal of Gastroenterology : WJG·Saurabh Kumar PatelGopal Nath

❮ Previous
Next ❯

Citations

Sep 29, 2020·Expert Opinion on Therapeutic Patents·Rossella GrandeRaffaella Muraro
May 14, 2021·Frontiers in Cellular and Infection Microbiology·Paweł Krzyżek

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy
transmission electron microscopy
electron microscopy
PCR
biopsy

Software Mentioned

Scopus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Infectious Diseases
L Cellini
American Journal of Clinical Pathology
W Y ChanC S Ng
Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
H TaguchiT Osaki
© 2021 Meta ULC. All rights reserved