Transformation of rat tracheal epithelial cells by benzo[a]pyrene and its metabolites

Cancer Letters
V E SteeleG M Cohen

Abstract

Benzo[a]pyrene (B[a]P) and its 7,8-dihydrodiol form were metabolically activated to malignantly transform a non-tumorigenic rat tracheal epithelial cell line in culture. The proximal carcinogenic metabolite of B[a]P, diolepoxide I, was more efficient in transforming the epithelial cell line than the intermediate or parent compound, even at a 50- or 100-fold lower concentration, respectively. Inoculations of the transformed cell lines into immunosuppressed isogenic recipients produced differentiated carcinomas similar to those which occur in humans.

References

Jul 15, 1976·Biochemical Pharmacology·G M Cohen, B P Moore

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Citations

Apr 1, 1990·Mutation Research·M J MassS J Austin
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M R StampferJ C Bartley
Jan 1, 1989·Environmental and Molecular Mutagenesis·V E SteeleM J Mass
Oct 31, 1989·Biochemical and Biophysical Research Communications·M J MassS J Austin

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