Transformation of stimulus correlations by the retina

PLoS Computational Biology
Kristina D SimmonsVijay Balasubramanian

Abstract

Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simultaneous responses from populations of retinal ganglion cells presented with natural and artificial stimuli that varied greatly in correlation structure; these stimuli and recordings are publicly available online. Responding to spatio-temporally structured stimuli such as natural movies, pairs of ganglion cells were modestly more correlated than in response to white noise checkerboards, but they were much less correlated than predicted by a non-adapting functional model of retinal response. Meanwhile, responding to stimuli with purely spatial correlations, pairs of ganglion cells showed increased correlations consistent with a static, non-adapting receptive field and nonlinearity. We found that in response to spatio-temporally correlated stimuli, ganglion cells had faster temporal kernels and tended to have stronger surrounds. These properties of individual cells, along with gain changes that opposed changes in effective contrast at ...Continue Reading

Associated Datasets

Nov 7, 2013·Philip C. NelsonGašper Tkačik

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Dec 18, 2013·PLoS Computational Biology·Kristina D SimmonsVijay Balasubramanian

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Citations

Dec 18, 2013·PLoS Computational Biology·Kristina D SimmonsVijay Balasubramanian
Jul 10, 2019·Annual Review of Vision Science·Alison I WeberAdrienne L Fairhall
Oct 4, 2017·PLoS Computational Biology·Marcel NonnenmacherJakob H Macke
Apr 14, 2017·PLoS Biology·Marcus H C HowlettMaarten Kamermans
Nov 26, 2018·Current Biology : CB·Emilio Salazar-GatzimasDamon A Clark
May 27, 2021·Cell Reports·Wei-Mien M HsuTatyana O Sharpee

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