Transformation of tetrabromobisphenol A by Rhodococcus jostii RHA1: Effects of heavy metals

Chemosphere
Shen XuAi-Jun Miao

Abstract

Tetrabromobisphenol A (TBBPA) is one of the most widely used brominated flame retardants in the world but it is also a pollutant of global concern. In the present study, we studied the transformation of 14C-labeled TBBPA by a polychlorinated-biphenyl-degrading bacterium, Rhodococcus jostii RHA1 (RHA1), under oxic conditions. During the 5-day incubation, TBBPA was biotransformed rapidly first to its monomethyl ether MeO-TBBPA and then to its more hydrophobic but less toxic dimethyl ether diMeO-TBBPA. The biotransformation followed pseudo-first-order decay kinetics, with a half-life of TBBPA of 0.32 days and only 0.6% of the initially added amount being mineralized. Considering the frequent co-occurrence of TBBPA with heavy metals in the natural environment, we also investigated the effects of three heavy metals (Cd, Cu, and Fe) on the transformation of TBBPA by strain RHA1. While TBBPA transformation was not significantly altered by Cd, it was accelerated by Cu and Fe, presumably due to the effects of these two essential metals on O-methyltransferase activity. Overall, the present study showed that RHA1 is an effective transformer of TBBPA and that certain essential metals, including Cu and Fe, promote the transformation.

Citations

Jun 19, 2019·Environmental Science and Pollution Research International·Chen GuFenbo Wang
Aug 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yujuan WenYuesuo Yang
Sep 25, 2019·Chemosphere·Obioma K MejehaNeil D Gray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.