Transformation potential of bone marrow stromal cells into undifferentiated high-grade pleomorphic sarcoma.

Journal of Cancer Research and Clinical Oncology
Qing LiSusumu Ikehara

Abstract

Bone marrow adherent cells contain conventional bone marrow stromal cells and mesenchymal stem cells and these cells constitute the hematopoietic microenvironment. Mesenchymal stem cells have the capacity to give rise to multiple mesenchymal lineage cells and even ectodermal lineage cells. In the present study, we investigated what types of tumor cells are inducible from BM adherent cells by chemical carcinogens. Bone marrow cells from neonatal C3H/HeN mice were collected within 24 h after birth and then cultured. Four days later, bone marrow adherent cells were obtained and the cells were treated with 3-methylcholanthrene. By this treatment, some transformed clones consisting of large spindle cells were obtained. The transformed cells were highly positive for CD44 and were positive for Sca-1, CD49d and CD106, whereas the cells were negative for hematolymphoid markers. The cell clones had the ability to support hematopoiesis in vitro. These results indicate that the transformed cell lines have the characteristics of BM stromal cells/mesenchymal stem cells. Moreover, during culture of the transformed cells, spontaneous bone nodule formation was observed. When the transformed cells were inoculated into immunodeficient mice subcut...Continue Reading

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Citations

Jul 25, 2013·Clinical Sarcoma Research·Wei XiaoAnne-Marie Cleton-Jansen
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Rita AlaggioSara O Vargas
Mar 23, 2011·Stem Cells·Alexander B Mohseny, Pancras C W Hogendoorn
Oct 8, 2014·Experimental and Therapeutic Medicine·Zhong-Bao RuanGe-Cai Chen
Nov 13, 2018·Frontiers in Oncology·Katia C GenadryCorinne M Linardic

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