Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand.

Molecular and Cellular Biology
F LiuJ Chernoff

Abstract

We have recently shown that protein tyrosine phosphatase 1B (PTP1B) associates with the docking protein p130Cas in 3Y1 rat fibroblasts. This interaction is mediated by a proline-rich sequence on PTP1B and the SH3 domain on p130Cas. Expression of wild-type PTP1B (WT-PTP1B), but not a catalytically competent, proline-to-alanine point mutant that cannot bind p130Cas (PA-PTP1B), causes substantial tyrosine dephosphorylation of p130Cas (F. Liu, D. E. Hill, and J. Chernoff, J. Biol. Chem. 271:31290-31295, 1996). Here we demonstrate that WT-, but not PA-PTP1B, inhibits transformation of rat 3Y1 fibroblasts by v-crk, -src, and -ras, but not by v-raf. These effects on transformation correlate with the phosphorylation status of p130Cas and two proteins that are associated with p130Cas, Paxillin and Fak. Expression of WT-PTP1B reduces formation of p130Cas-Crk complexes and inhibits mitogen-activated protein kinase activation by Src and Crk. These data show that transformation suppression by PTP1B requires a functional SH3 ligand and suggest that p130Cas may represent an important physiological target of PTP1B in cells.

References

Apr 1, 1992·The Journal of Cell Biology·T A Woodford-ThomasJ E Dixon
Sep 30, 1992·International Journal of Cancer. Journal International Du Cancer·S FumagalliL Larizza
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S B KannerJ T Parsons
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M F CicirelliE G Krebs
Aug 25, 1990·Nucleic Acids Research·M Schuermann
Jan 1, 1985·Annual Review of Biochemistry·T Hunter, J A Cooper
Jan 1, 1988·Annual Review of Biochemistry·Y Yarden, A Ullrich
Aug 1, 1987·Molecular and Cellular Biology·C Chen, H Okayama
Jan 23, 1995·Gene·M A Sells, J Chernoff
Apr 1, 1994·Trends in Biochemical Sciences·L J Mauro, J E Dixon
Dec 15, 1993·Biochemical and Biophysical Research Communications·Y KanekoJ Fujita
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·R G QiuM Symons
Apr 12, 1996·The Journal of Biological Chemistry·T NakamotoH Hirai
Mar 15, 1996·The Journal of Biological Chemistry·L BudayJ Downward
Feb 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S K Hanks, T R Polte
Jul 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·R B BirgeH Hanafusa
Oct 8, 1997·Proceedings of the Society for Experimental Biology and Medicine·J C ByonJ Kusari

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Citations

Jun 22, 2014·The American Journal of Pathology·Takanori KumagaiTomoko Takano
May 15, 2003·Diabetes & Metabolism·T IssadK Pernet
Sep 29, 2009·Biochimica Et Biophysica Acta·Laurent LessardMichel L Tremblay
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·K R LaMontagneN K Tonks
Jan 20, 2000·Journal of the National Cancer Institute·A BrinkmanL C Dorssers
Apr 6, 2017·Journal of Zhejiang University. Science. B·Shi-Chong LiaoSheng-Rong Sun
Apr 16, 1998·Current Biology : CB·F LiuJ Chernoff
Jul 8, 1999·Journal of Cellular Physiology·J Chernoff
Dec 13, 2006·Nature Cell Biology·Shrikrishna DadkeJonathan Chernoff
Apr 29, 2006·Molecular & Cellular Proteomics : MCP·Yukihito KabuyamaNatalie G Ahn
Aug 27, 2013·Cellular and Molecular Life Sciences : CMLS·Radoslav JanoštiakDaniel Rösel
Aug 7, 2003·The Journal of Biological Chemistry·Shrikrishna Dadke, Jonathan Chernoff
Feb 1, 2008·Cancer Metastasis Reviews·Matthew StuibleMichel L Tremblay
Feb 25, 2006·The Journal of Biological Chemistry·Keith BurridgeJennifer L Sallee
Apr 19, 2006·The Journal of Biological Chemistry·James S SwaneyPaul A Insel
Apr 23, 2014·Molecular Genetics and Genomics : MGG·Stéphane Tchankouo-NguetcheuLeonard Rabinow
Jun 29, 2011·The Biochemical Journal·Chia-Lun WuTzu-Ching Meng
Sep 30, 2008·The Journal of Biological Chemistry·Veena SangwanMorag Park
Oct 18, 2001·Molecular and Cellular Biology·P J RuestS K Hanks
Jul 29, 2011·The Journal of Biological Chemistry·Daniel AlviraThomas G Cotter
Jan 11, 2005·The Journal of Biological Chemistry·Jonathan H LiemanJ William Harbour
Mar 16, 2002·Infection and Immunity·José E Teixeira, Barbara J Mann
Sep 22, 1999·Molecular and Cellular Biology·Y Hakak, G S Martin
Mar 10, 2007·Cancer Research·Mohamed Bentires-Alj, Benjamin G Neel
Jan 21, 2000·Experimental Cell Research·A JazayeriB E Bejcek

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