Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations

Molecular Microbiology
Y ZhangD B Young

Abstract

Isoniazid-resistant isolates of Mycobacterium tuberculosis were transformed with a plasmid vector carrying the functional catalase-peroxidase (katG) gene. Expression of katG restored full drug susceptibility in isolates initially resistant to concentrations ranging from 3.2 to > 50 micrograms ml-1. Transformation with the corresponding katG gene from Escherichia coli resulted in low-level expression of catalase and peroxidase activities and conferred partial isoniazid sensitivity.

References

Aug 21, 1992·Science·B R Bloom, C J Murray
Apr 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·M H LeeG F Hatfull
Jun 6, 1991·Nature·C K StoverG F Hatfull
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S B SnapperW R Jacobs

❮ Previous
Next ❯

Citations

Sep 25, 2004·Medicinal Research Reviews·Rama P TripathiVinod K Tiwari
Nov 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Salfinger, G E Pfyffer
Feb 1, 1993·Research in Microbiology·Y Zhang
Jan 1, 1996·Research in Microbiology·N Rastogi, J O Falkinham
Jan 1, 1996·Research in Microbiology·J C Sacchettini, J S Blanchard
Jul 1, 1996·Trends in Microbiology·C E Barry, K Mdluli
Jan 7, 1998·Biochemical Pharmacology·C E Barry
Oct 5, 2001·FEMS Microbiology Letters·Z SunY Zhang
Jul 8, 2000·Microbes and Infection·R A Slayden, C E Barry
Jul 14, 2011·Nature Reviews. Rheumatology·Edward S Chen, David R Moller
Jan 14, 2003·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Stephen H GillespieTimothy D McHugh
Jan 15, 2005·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·L MoZ W Chen
Apr 3, 2010·The Journal of Antimicrobial Chemotherapy·Wanliang Shi, Ying Zhang
Dec 14, 2001·Protein Science : a Publication of the Protein Society·Shengwei YuRichard S Magliozzo
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Salman SiddiqiYing Zhang
Jun 23, 2010·Antimicrobial Agents and Chemotherapy·Feng WangJames C Sacchettini
Aug 1, 1994·Antimicrobial Agents and Chemotherapy·J L Rosner, G Storz
Jan 18, 2002·Antimicrobial Agents and Chemotherapy·Stephen H Gillespie
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Vanja M BulatovicFrank Rusnak
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Miguel ViveirosLeonard Amaral
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Stéphanie Ducasse-CabanotAnnaïk Quémard
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Rosilene Fressatti CardosoMario H Hirata
Jan 28, 2005·Antimicrobial Agents and Chemotherapy·Catherine VilchèzeWilliam R Jacobs
Jun 13, 2000·Journal of Bacteriology·M GuoY Zhang
Nov 1, 1996·Journal of Clinical Pathology·M JaberR Kumar
Nov 24, 2007·Annual Review of Microbiology·Catherine Vilchèze, William R Jacobs
Mar 1, 1995·The Journal of Clinical Investigation·N A BuchmeierF C Fang
Jun 11, 1998·Emerging Infectious Diseases·A RattanN Ahmad
Jun 4, 2015·Emerging Microbes & Infections·Wanliang ShiYing Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.