PMID: 10652352Feb 1, 2000Paper

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway

The Journal of Biological Chemistry
C Ségouffin-Cariou, M Billaud

Abstract

The RET gene codes for a receptor tyrosine kinase that plays a crucial role during the development of both the enteric nervous system and the kidney. Germ line missense mutations at one of six codons specifying extracytoplasmic cysteines are responsible for two related cancer disorders as follows: multiple endocrine neoplasia type2A (MEN2A) and familial medullary thyroid carcinoma (FMTC). MEN2A and FMTC mutations result in a constitutive catalytic activity and as a consequence convert RET into a dominantly acting transforming gene. Although it has been shown that RET-MEN2 mutants activate several transduction pathways, their respective contribution to the neoplastic phenotype remains poorly understood. Over the past few years, it has become increasingly clear that the transforming ability of several viral and cellular oncoproteins depends on their capacity to activate phosphatidylinositol 3-kinase (PI3K). We now report that RET carrying a representative MEN2A mutation at Cys-634 (termed RET-MEN2A) activates PI3K and its downstream effector, the serine/threonine kinase AKT/protein kinase B. Previous studies have demonstrated that mutation of Tyr-1062, which is the intracellular docking site for Shc and Enigma on RET, abolishes t...Continue Reading

References

Nov 27, 1991·Biochemical and Biophysical Research Communications·M TaniguchiM Takahashi
Mar 12, 1993·Cell·Z SongyangR J Lechleider
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W S PearD Baltimore
Jul 1, 1993·Human Molecular Genetics·H Donis-KellerS A Wells
May 31, 1996·The Journal of Biological Chemistry·K DurickS S Taylor
Oct 1, 1996·Human Molecular Genetics·T IwashitaM Takahashi
Feb 20, 1997·Oncogene·E ArighiM G Borrello
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·F M MichielsM Billaud
Sep 25, 1997·Trends in Biochemical Sciences·B M Marte, J Downward
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·M Holgado-MadrugaA J Wong
Apr 30, 1998·Current Opinion in Cell Biology·J Downward
Oct 6, 1998·Annual Review of Biochemistry·D A FrumanL C Cantley
Oct 9, 1998·Oncogene·L AlbertiM A Pierotti
Nov 13, 1998·Science·M H CardoneJ C Reed
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L C Cantley, B G Neel
Jun 5, 1999·Molecular and Cellular Neurosciences·M S AiraksinenM Saarma

❮ Previous
Next ❯

Citations

Jan 19, 2013·Apoptosis : an International Journal on Programmed Cell Death·Minakshi MazumdarTanya Das
May 11, 2005·Familial Cancer·Mariola Peczkowska, Andrzej Januszewicz
Feb 11, 2012·Endocrine Pathology·Alberto Cascón, Daniel A Tennant
Mar 7, 2012·Endocrine Pathology·Svenja Nölting, Ashley B Grossman
Jun 12, 2002·Biochemical and Biophysical Research Communications·Naoko IwahashiMasahide Takahashi
Mar 12, 2004·Cancer Letters·Masatoshi IchiharaMasahide Takahashi
Sep 7, 2001·Cytokine & Growth Factor Reviews·M Takahashi
Feb 16, 2010·Nature Genetics·Yuejuan QinPatricia L M Dahia
Jun 21, 2011·Nature Genetics·Iñaki Comino-MéndezAlberto Cascón
Aug 25, 2011·Nature Reviews. Endocrinology·Matti L GildRoderick Clifton-Bligh
Jan 17, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J MatroK Pacak
May 15, 2001·Thyroid : Official Journal of the American Thyroid Association·J SaitoM D Ringel
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Maria A KouvarakiDouglas B Evans
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Phillip H Abbosh, Kenneth P Nephew
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Tirtha Das, Ross Cagan
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Mingzhao Xing
Jul 9, 2004·Journal of the National Cancer Institute·Giuditta CuccuruFranco Zunino
Aug 19, 2004·Journal of the National Cancer Institute·Matthias DrostenBrigitte M Pützer
Aug 14, 2013·Journal of the National Cancer Institute·Ivana JochmanováKarel Pacak
Feb 3, 2006·Genes & Development·Sanjay JainJeffrey Milbrandt
Apr 26, 2006·Pathology International·Naoya AsaiMasahide Takahashi
Sep 13, 2000·Molecular and Cellular Biology·H GuB G Neel
Sep 2, 2004·Molecular and Cellular Biology·Mayumi JijiwaMasahide Takahashi
Nov 10, 2000·Journal of Medical Genetics·J R Hansford, L M Mulligan
Nov 1, 2001·Annual Review of Cell and Developmental Biology·R KatsoM D Waterfield
Nov 2, 2011·Endocrine-related Cancer·Jenny WelanderOliver Gimm
Mar 6, 2012·Endocrine-related Cancer·Joanna Klubo-GwiezdzinskaVasyl Vasko
Jun 21, 2005·Genetics·Renee D ReadRoss L Cagan
Mar 10, 2001·Biochemical and Biophysical Research Communications·Y HayashiM Takahashi
Feb 25, 2014·Nature Reviews. Cancer·Lois M Mulligan
May 7, 2014·Thyroid : Official Journal of the American Thyroid Association·Minjing ZouYufei Shi
Dec 19, 2015·Critical Reviews in Clinical Laboratory Sciences·Mehdi HedayatiFarinaz Afsari
Mar 7, 2013·Expert Opinion on Therapeutic Targets·Maria Grazia BorrelloMarco A Pierotti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.