Transforming G proteins

Oncogene
V Radhika, N Dhanasekaran

Abstract

Heterotrimeric guanine nucleotide binding proteins, commonly known as G proteins form a super-family of signal transduction proteins. They are peripherally associated with the plasma membrane and provide signal coupling to seven transmembrane surface receptors. G proteins are composed of monomers of alpha, beta, and gamma subunits. The beta- and gamma-subunits are tightly associated. The receptors activated by the appropriate "signal", interact catalytically with specific G-proteins to mediate guanine nucleotide exchange at the GDP/GTP binding site of the G-protein alpha-subunits, thus displacing the bound GDP for GTP. The GTP bound form of the g-protein alpha-subunit and in some cases the free betagamma-subunits initiate cellular response by altering the activity of specific effector molecules. Recent studies have indicated that the asyncronous activation of these proteins can lead to the oncogenic transformation of different cell types. The mechanism by which G-proteins regulate the various cell functions appear to involve a complex net-working between different signaling pathways. This review summarizes the signaling mechanisms involved in the regulation of cell proliferation by these transforming G proteins.

References

Jan 1, 1992·Annual Review of Physiology·J Pouysségur, K Seuwen
Oct 1, 1992·Molecular and Cellular Biology·G KalinecJ S Gutkind
Jan 1, 1992·Molecular Biology of the Cell·S K GuptaG L Johnson
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A M PaceH R Bourne
Jan 1, 1992·Molecular and Cellular Biology·S K GuptaG L Johnson
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J S GutkindK C Robbins
Aug 10, 1990·Science·J LyonsH R Bourne
May 16, 1990·Biochemical and Biophysical Research Communications·I ZacharyH R Bourne
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M StrathmannM I Simon
Feb 1, 1989·Trends in Biochemical Sciences·J E DumontP P Roger
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M R SmithH F Kung
Feb 12, 1966·Nature·T R Shantha Veerappa, G H Bourne
Jun 1, 1995·Trends in Biochemical Sciences·Y TakaiH Nakanishi
Oct 20, 1995·The Journal of Biological Chemistry·A M BuhlG L Johnson
Aug 31, 1995·Nature·H R Bourne
Jun 1, 1995·Endocrine Reviews·N DhanasekaranG L Johnson
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L M GravesE G Krebs
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B R SevetsonJ C Lawrence
Nov 12, 1993·Science·S J Cook, F McCormick
Jun 15, 1994·Biochemical and Biophysical Research Communications·N XuJ S Gutkind
Apr 1, 1994·Journal of Cellular Biochemistry·G L JohnsonS Winitz
May 1, 1994·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·B H WeberO Riess
Nov 1, 1993·Biochemical Society Transactions·B M BurgeringJ L Bos
May 1, 1993·Annals of Epidemiology·G S Omenn
Sep 1, 1993·The Journal of Clinical Endocrinology and Metabolism·K TordjmanE Friedman
Sep 20, 1993·FEBS Letters·H JiangM I Simon
Feb 1, 1993·Molecular and Cellular Biology·A M ChanS A Aaronson
Jan 1, 1993·Australian Veterinary Journal·G L ReddacliffD W Cooper
Mar 15, 1996·The Journal of Biological Chemistry·R HooleyD L Barber
Jul 19, 1996·The Journal of Biological Chemistry·L R CollinsJ H Brown
Oct 1, 1996·Molecular and Cellular Biology·H MischakW Kolch
Jun 1, 1996·Cellular Signalling·N Dhanasekaran, J M Dermott

❮ Previous
Next ❯

Citations

Aug 6, 2005·Biochemical and Biophysical Research Communications·Jingzhen YuanEnrique Rozengurt
Mar 8, 2005·Trends in Pharmacological Sciences·Natalia A Riobo, David R Manning
Jun 5, 2003·Medical Hypotheses·Bruno VincenziGiuseppe Tonini
Mar 8, 2002·Cellular Signalling·Eun Mi Hur, Kyong Tai Kim
Sep 27, 2007·ACS Chemical Biology·Steven W MillwardRichard W Roberts
Jun 23, 2007·Nature Reviews. Drug Discovery·Panagiotis A KonstantinopoulosAthanasios G Papavassiliou
Jan 5, 2011·Nature Reviews. Drug Discovery·Rosamaria Lappano, Marcello Maggiolini
Feb 15, 2011·Oncogene·M Garcia-MarcosM G Farquhar
May 15, 2007·Oncogene·Z G Goldsmith, D N Dhanasekaran
Apr 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Joachim H C OrthKlaus Aktories
Nov 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joachim H C OrthKlaus Aktories
Dec 16, 2005·Molecular and Cellular Biology·Rashmi N KumarDanny N Dhanasekaran
Feb 13, 2009·Neuro-Signals·Nobuchika SuzukiTohru Kozasa
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken YamakawKimio Tomita
Sep 1, 2009·PloS One·Simona LambaAlberto Bardelli
May 9, 2012·The Journal of Endocrinology·Melyssa R BrattonMatthew E Burow
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·David MaussangMartine J Smit
May 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Patrick KellyPatrick J Casey
Apr 28, 2005·Oncogene·V RadhikaN Dhanasekaran
Mar 25, 2009·The Journal of Cell Biology·Fang LinLilianna Solnica-Krezel
Jun 30, 2009·Biochemical Pharmacology·Jillian H Hurst, Shelley B Hooks
Dec 26, 2006·Current Opinion in Genetics & Development·Bryan D Spiegelberg, Heidi E Hamm
Jul 1, 2004·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Aljosa Bavec
May 9, 2009·British Journal of Pharmacology·Juhi Juneja, Patrick J Casey
Dec 18, 2008·Proteins·Kamil KhafizovPaolo Carloni
Oct 28, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Keith C ChengJanet D Robishaw
Aug 25, 2010·International Journal of Cancer. Journal International Du Cancer·Chunfa HuangR Tyler Miller
Sep 1, 2004·Cellular Signalling·Silvio NaviglioGennaro Illiano
Apr 3, 2003·Biochemical and Biophysical Research Communications·Eddy H T WuYung H Wong
Apr 17, 2016·Biochemical and Biophysical Research Communications·Bo YuanKehong Deng
Oct 16, 2014·Pathology Oncology Research : POR·Heidi V N Küsters-VandeveldePatricia J T A Groenen
Feb 19, 2011·Communicative & Integrative Biology·Hagit TurmRachel Bar-Shavit

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.