Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease

American Journal of Respiratory Cell and Molecular Biology
Yael Aschner, Gregory P Downey

Abstract

In this article, we review the biology and physiological importance of transforming growth factor-β (TGF-β) to homeostasis in the respiratory system, its importance to innate and adaptive immune responses in the lung, and its pathophysiological role in various chronic pulmonary diseases including pulmonary arterial hypertension, chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. The TGF-β family is responsible for initiation of the intracellular signaling pathways that direct numerous cellular activities including proliferation, differentiation, extracellular matrix synthesis, and apoptosis. When TGF-β signaling is dysregulated or essential control mechanisms are unbalanced, the consequences of organ and tissue dysfunction can be profound. The complexities and myriad checkpoints built into the TGF-β signaling pathways provide attractive targets for the treatment of these disease states, many of which are currently being investigated. This review focuses on those aspects of TGF-β biology that are most relevant to pulmonary diseases and that hold promise as novel therapeutic targets.

References

Aug 1, 1991·American Journal of Respiratory Cell and Molecular Biology·N KhalilA H Greenberg
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M WahlM B Sporn
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
May 1, 1994·The Journal of Clinical Investigation·G A Stouffer, G K Owens
Jul 10, 1998·Cell·S E CrawfordN Bouck
Apr 10, 1999·Genes & Development·M KretzschmarJ Massagué
Sep 1, 1999·Journal of Dermatological Science·C QuerfeldS Sollberg
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·N KaminskiR A Heller
Sep 6, 2000·Nature Genetics·UNKNOWN International PPH ConsortiumR C Trembath
Dec 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L A MillerD M Hyde
Dec 12, 2001·Nature Cell Biology·Chuan-Wei JangRuey-Hwa Chen
Jan 26, 2002·Cell and Tissue Research·Norbert Schuster, Kerstin Krieglstein
Feb 14, 2002·The Journal of Investigative Dermatology·Franck Verrecchia, Alain Mauviel
Mar 14, 2002·The American Journal of Pathology·Kathleen C FlandersAnita B Roberts
Oct 24, 2002·The European Respiratory Journal. Supplement·K F Chung
Dec 18, 2002·Annals of the New York Academy of Sciences·John A MarwickIrfan Rahman
Mar 14, 2003·Nature·Anita B Roberts
Apr 30, 2003·Nature Cell Biology·Gianni M Di GuglielmoJeffrey L Wrana
Jun 13, 2003·American Journal of Physiology. Cell Physiology·Bernard A J RoelenHerbert Y Lin
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Nov 5, 2003·The Journal of Pathology·Eric S WhiteVictor J Thannickal
Feb 11, 2004·Chest·Ulrike Bartram, Christian P Speer
Mar 3, 2004·Nature Reviews. Molecular Cell Biology·Lan Xu, Joan Massagué
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew Leask, David J Abraham
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·Philippe BonniaudJack Gauldie
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah J McMillanClare M Lloyd

❮ Previous
Next ❯

Citations

Oct 23, 2016·The Journal of Pathology·Lijiang Ma, Wendy K Chung
Sep 8, 2016·American Journal of Respiratory Cell and Molecular Biology·Belinda J ThomasPhilip G Bardin
Apr 18, 2018·Journal of Cellular Biochemistry·Dhamotharan PattarayanSubbiah Rajasekaran
Sep 18, 2017·Cellular and Molecular Life Sciences : CMLS·David N O'Dwyer, Bethany B Moore
Jun 24, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Huili ZhangJesse D Roberts
Aug 4, 2018·International Journal of Molecular Sciences·Toshihiko KomaiKeishi Fujio
Nov 15, 2018·Physiological Reviews·Jeffrey A WhitsettVladimir V Kalinichenko
Nov 24, 2018·Expert Opinion on Therapeutic Targets·Vishwaraj SontakeSatish K Madala
Jun 16, 2018·F1000Research·Ajay P NayakRaymond B Penn
Aug 18, 2018·The European Respiratory Journal·Reinoud Gosens, Nicholas Gross
Feb 14, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Subhendu MukherjeeLuke J Janssen
Sep 11, 2016·Clinical Science·Motoko TakahashiNaoyuki Taniguchi
Oct 1, 2019·Plastic and Reconstructive Surgery·Ashley L TitanMichael T Longaker
Jan 11, 2020·American Journal of Respiratory Cell and Molecular Biology·Elizabeth L KramerJohn P Clancy
Feb 20, 2018·Experimental and Therapeutic Medicine·Lei YangLiang Dong
Sep 10, 2017·Alcoholism, Clinical and Experimental Research·Lucian T MartsViranuj Sueblinvong
Nov 24, 2017·Expert Opinion on Therapeutic Targets·Elizabeth L Kramer, John P Clancy
Jun 27, 2020·Current Stem Cell Reports·Aravind Sivakumar, David B Frank
Apr 29, 2018·Scientific Reports·Anda R GligaHanna L Karlsson
May 31, 2018·American Journal of Respiratory Cell and Molecular Biology·Yael Aschner, Gregory P Downey
Jun 6, 2020·NAR Genomics and Bioinformatics·William D StuartYutaka Maeda
Aug 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jose G MontoyaMark M Davis
Sep 22, 2017·American Journal of Respiratory Cell and Molecular Biology·Mahyar AghapourIrene H Heijink
Aug 10, 2018·Frontiers in Physiology·Paul B DieffenbachLaura E Fredenburgh
Oct 4, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Birgit BlissenbachJacqueline Pichler Hefti
Aug 25, 2018·American Journal of Respiratory Cell and Molecular Biology·Lauren M Doolittle, Ian C Davis
Aug 22, 2018·International Journal of Molecular Sciences·Akira SaitoTakahide Nagase
Jul 17, 2020·Scientific Reports·Julianne N P SmithAmar B Desai
Jun 4, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yael AschnerGregory P Downey
Aug 25, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Antonino Di StefanoMaria Graziella Catalano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2022 Meta ULC. All rights reserved