Transforming growth factor-β (TGF-β) signaling in healthy human fetal skin: a descriptive study

Journal of Dermatological Science
Mariëlle WalravenMagda M W Ulrich

Abstract

TGF-β plays an important role in growth and development but is also involved in scarring and fibrosis. Differences for this growth factor are known between scarless fetal wound healing and adult wound healing. Nonetheless, most of the data in this area are from animal studies or in vitro studies and, thus, information about the human situation is incomplete and scarce. The aim of this study was to compare the canonical TGF-β signaling in unwounded human fetal and adult skin. Q-PCR, immunohistochemistry, Western Blot and Luminex assays were used to determine gene expression, protein levels and protein localization of components of this pathway in healthy skin. All components of the canonical TGF-β pathway were present in unwounded fetal skin. Compared to adult skin, fetal skin had differential concentrations of the TGF-β isoforms, had high levels of phosphorylated receptor-Smads, especially in the epidermis, and had low expression of several fibrosis-associated target genes. Further, the results indicated that the processes of receptor endocytosis might also differ between fetal and adult skin. This descriptive study showed that there are differences in gene expression, protein concentrations and protein localization for most co...Continue Reading

References

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Citations

Feb 20, 2016·American Journal of Clinical Dermatology·Anthony P TraceValerie M Harvey
Oct 11, 2017·Journal of Biomaterials Applications·Daniela SteffensPatricia Pranke
Dec 5, 2017·Signal Transduction and Targeted Therapy·Zhong ZhengChia Soo
Jul 15, 2017·Clinical Science·Steven HorsburghSteven O'Reilly
Apr 25, 2020·Nutrients·Bożena Kociszewska-NajmanJacek Malejczyk
Feb 14, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Mariëlle WalravenMagda M W Ulrich
Feb 18, 2020·Frontiers in Pharmacology·Xiaoxiao PangZhong Zheng
Jan 23, 2021·Journal of Cell Communication and Signaling·René Fernando Abarca-BuisEdgar Krötzsch

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