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Transforming growth factor-β1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice

American Journal of Physiology. Renal Physiology

Mar 1, 2013

Carolina I GalarretaRobert L Chevalier

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Abstract

Unilateral ureteral obstruction (UUO), a widely used model of chronic kidney disease and congenital obstructive uropathy, causes proximal tubular injury and formation of atubular glomeruli. Because transforming growth factor-β1 (TGF-β1) is a central regulator of renal injury, neonatal a...read more

Mentioned in this Paper

Mice, Inbred C57BL
General Anesthesia [PE]
Recombinant Transforming Growth Factor
Cerebral Hemorrhage
Chronic Kidney Insufficiency
Collagen Location
Collagen Activity
Renal Tubule Structure
TGFBR1 gene
Metabolic Inhibition
Paper Details
References
  • References37
  • Citations6
1234

Transforming growth factor-β1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice

American Journal of Physiology. Renal Physiology

Mar 1, 2013

Carolina I GalarretaRobert L Chevalier

PMID: 23303407

DOI: 10.1152/ajprenal.00496.2012

Abstract

Unilateral ureteral obstruction (UUO), a widely used model of chronic kidney disease and congenital obstructive uropathy, causes proximal tubular injury and formation of atubular glomeruli. Because transforming growth factor-β1 (TGF-β1) is a central regulator of renal injury, neonatal a...read more

Mentioned in this Paper

Mice, Inbred C57BL
General Anesthesia [PE]
Recombinant Transforming Growth Factor
Cerebral Hemorrhage
Chronic Kidney Insufficiency

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Paper Details
References
  • References37
  • Citations6
1234

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