Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions

Clinical & Translational Immunology
David Bauché, Julien C Marie

Abstract

The relationship between host organisms and their microbiota has co-evolved towards an inter-dependent network of mutualistic interactions. This interplay is particularly well studied in the gastrointestinal tract, where microbiota and host immune cells can modulate each other directly, as well as indirectly, through the production and release of chemical molecules and signals. In this review, we define the functional impact of transforming growth factor-beta (TGF-β) on this complex interplay, especially through its modulation of the activity of local regulatory T cells (Tregs), type 17 helper (Th17) cells, innate lymphoid cells (ILCs) and B cells.

References

May 23, 1998·Annual Review of Immunology·J J Letterio, A B Roberts
Jun 5, 2002·The Journal of Experimental Medicine·Leonid GorelikRichard A Flavell
Jan 1, 2004·Genes & Development·Joan Massague
Apr 6, 2005·The Journal of Experimental Medicine·Julien C MarieAlexander Y Rudensky
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jörg KleinBurkhard Kneitz
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pascal DescarguesMichael Karin
Apr 11, 2008·Immunity·Mandy J McGeachy, Daniel J Cua
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sheng XiaoVijay K Kuchroo
Aug 22, 2008·Nature·Koji AtarashiKiyoshi Takeda
May 20, 2009·The Journal of Experimental Medicine·Jean-Marc DoisneJulien C Marie
Nov 6, 2009·The Journal of Biological Chemistry·Gustavo J MartinezChen Dong
Apr 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Takashi ObataHiroshi Kiyono
Jul 30, 2010·The Journal of Biological Chemistry·Gustavo J MartinezChen Dong
Oct 22, 2010·Nature·Kamran GhoreschiJohn J O'Shea
Sep 23, 2011·Nature·Stephanie K LathropChyi-Song Hsieh
Oct 7, 2011·Mucosal Immunology·N J MantisB Corthésy
Feb 10, 2012·Nature·Steven Z JosefowiczAlexander Y Rudensky

❮ Previous
Next ❯

Citations

Apr 27, 2019·Annual Review of Immunology·Onyinye I Iweala, Cathryn R Nagler
Jul 7, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yizhan GuoAlexander Sasha Krupnick
Sep 5, 2019·Journal of Leukocyte Biology·Suhas SureshchandraIlhem Messaoudi
Jan 29, 2020·Nature Reviews. Immunology·George V SharonovDmitriy M Chudakov
Jun 6, 2018·Clinical & Translational Immunology·Mubing Duan
Jan 10, 2020·Digestive Diseases and Sciences·Meenal SinghCraig A Friesen
Nov 10, 2017·Mediators of Inflammation·Danilo PagliariRossella Cianci
Jul 6, 2019·Journal of Cachexia, Sarcopenia and Muscle·Joanna D C C LimaMarilia Seelaender
Apr 29, 2020·Antioxidants·Justyna GodosGiuseppe Grosso
Sep 9, 2020·Nature Materials·Geraldine M JowettEileen Gentleman
May 10, 2020·Cancers·Purushottam LamichhaneRahul R Deshmukh
Dec 11, 2020·Gut Microbes·André A SantosCecília M P Rodrigues
Aug 2, 2019·Ageing Research Reviews·Jacopo J V BrancaClaudio Nicoletti
Oct 29, 2020·Genome Medicine·Michael R GoldbergOmry Koren
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Mona DehhaghiGilles J Guillemin
Dec 31, 2020·Biomolecules·Carmine StolfiGiovanni Monteleone
Feb 23, 2021·Microbiome·Antonio ReverterYuliaxis Ramayo-Caldas
May 1, 2021·International Journal of Molecular Sciences·Edoardo TronconeGiovanni Monteleone
May 1, 2021·Immunology and Cell Biology·Laura CookMegan K Levings
Jun 4, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Zhuanhuai WangLopa Mishra

❮ Previous
Next ❯

Methods Mentioned

BETA
IECs

Related Concepts

Related Feeds

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Gianluigi FerrettiMario Mandala
European Journal of Biochemistry
K Unsicker
© 2022 Meta ULC. All rights reserved