Transforming growth factor alpha acts as a gliatrophin for mouse and human astrocytes

Oncogene
Ariane SharifM P Junier

Abstract

Astrocyte death has been implicated in several neuropathological diseases, but the identification of molecules susceptible of promoting astrocyte survival has been elusive. We investigated whether transforming growth factor alpha (TGFalpha), an erbB1/EGFR ligand, which promotes glioma progression and affects astrocyte metabolism at embryonic and adult stages, regulates astrocyte survival. Primary serum-free astrocyte cultures from post-natal mouse and fetal human cortices were used. Transforming growth factor alpha protected both species of astrocytes from staurosporine-induced apoptosis. In serum-free medium, mouse astrocytes did not survive beyond 2 months while TGFalpha-treated astrocytes survived up to 12 months. Transforming growth factor alpha also promoted long-term survival of human astrocytes. We additionally extended TGFalpha proliferative effects to human astrocytes. After 3 days of permanent application, TGFalpha induced a major downregulation of both erbB1 and erbB2. This downregulation did not impair the functional activation of the receptors, as ascertained by their tyrosine phosphorylation and the continuous stimulation of both ERK/MAPK and PI3K/Akt pathways up to 7 days, the longest time examined. The full cell...Continue Reading

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Citations

Apr 20, 2011·Biologie aujourd'hui·Marie-Pierre Junier, Ariane Sharif
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robin E WhiteLyn B Jakeman
Jan 14, 2009·Neurological Research·William R ShankleIsmael Mena
May 15, 2010·Journal of Neuropathology and Experimental Neurology·Véronique Duhem-TonnelleAriane Sharif
Jun 16, 2010·Frontiers in Neuroendocrinology·Vincent PrevotMarc Baroncini
Jul 19, 2008·Cell Biochemistry and Function·Yingfeng ZhengZhihong Zheng
Oct 22, 2008·Biochimica Et Biophysica Acta·Anne-Laure SurenaMarie-Pierre Junier
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Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephan BarrientosMarjana Tomic-Canic

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