Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth

Bone
Shirine E UsmaniFrank Beier

Abstract

We have recently identified transforming growth factor alpha (TGFα) as a novel growth factor involved in the joint disease osteoarthritis. The role of TGFα in normal cartilage and bone physiology however, has not been well defined. The objective of this study was to determine the role of TGFα in bone development through investigation of the Tgfa knockout mouse. The gross skeletons as well as the cartilage growth plates of Tgfa knockout mice and their control littermates were examined during several developmental stages ranging from newborn to ten weeks old. Knockout mice experienced skeletal growth retardation and expansion of the hypertrophic zone of the growth plate. These phenotypes were transient and spontaneously resolved by ten weeks of age. Tgfa knockout growth plates also had fewer osteoclasts along the cartilage/bone interface. Furthermore, knockout mice expressed less RUNX2, RANKL, and MMP13 mRNA in their cartilage growth plates than controls did. Tgfa knockout mice experience a delay in bone development, specifically the conversion of hypertrophic cartilage to true bone. The persistence of the hypertrophic zone of the growth plate appears to be mediated by a decrease in MMP13 and RANKL expression in hypertrophic chon...Continue Reading

References

May 1, 1995·Cell Biology International·V KumarI A McKay
Mar 12, 1999·Mechanisms of Development·I S KimS Mundlos
Sep 26, 2000·The Journal of Biological Chemistry·S Y Chan, R W Wong
Apr 3, 2001·Trends in Cardiovascular Medicine·H P Gerber, N Ferrara
Aug 9, 2002·Molecular and Cellular Biology·Valérie GeoffroyPatrick Matthias
Mar 22, 2003·Experimental Cell Research·Raymond C HarrisRobert J Coffey
May 16, 2003·Nature·Henry M Kronenberg
Sep 6, 2003·Birth Defects Research. Part C, Embryo Today : Reviews·R Tracy Ballock, Regis J O'Keefe
Jun 3, 2004·Biomaterials·Dominique P Pioletti, Arlette Kottelat
Sep 25, 2004·Journal of Cellular Physiology·Frank Beier
Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Masaki InadaStephen M Krane
Dec 18, 2004·Endocrinology·Tatsuya Kobayashi, Henry Kronenberg
Feb 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ola Nilsson, Jeffrey Baron
May 1, 2007·Developmental Biology·Guoyan WangFrank Beier
May 29, 2007·Arthritis and Rheumatism·C T G AppletonF Beier
Jul 31, 2007·The International Journal of Biochemistry & Cell Biology·E J MackieM Mirams
Oct 31, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michihiko UsuiBrendan F Boyce
Sep 24, 2009·PloS One·Lauren A SolomonFrank Beier
Oct 13, 2009·Trends in Endocrinology and Metabolism : TEM·Marlon R SchneiderReinhold G Erben
Jan 30, 2010·PloS One·Veronica UliciFrank Beier
Apr 27, 2011·Journal of Cellular Physiology·Antonella De LucaNicola Normanno
Sep 3, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xianrong ZhangLing Qin

❮ Previous
Next ❯

Citations

Jun 5, 2013·Molecular and Cellular Biology·Katherine C HallCarl P Blobel
Mar 19, 2014·Biochimica Et Biophysica Acta·Zhuo LiDennis E Vance
Nov 18, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Zhijun ChenShunichi Murakami
Mar 29, 2014·Birth Defects Research. Part C, Embryo Today : Reviews·Margaret Man-Ger Sun, Frank Beier
May 24, 2014·Osteoarthritis and Cartilage·M M-G Sun, F Beier
Jul 4, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paxton M MoonFrank Beier
Apr 13, 2015·Current Opinion in Pharmacology·Mary B Goldring, Francis Berenbaum
Oct 5, 2016·PLoS Genetics·Martha C Castaño-BetancourtJoyce B J van Meurs
Jul 28, 2016·Scientific Reports·Shirine E UsmaniFrank Beier
Aug 5, 2017·Genetic Testing and Molecular Biomarkers·Guofeng CuiKunzheng Wang
Oct 5, 2017·Endocrinology·Dai SuzukiFrank Beier
Dec 22, 2019·Biomechanics and Modeling in Mechanobiology·Andrés Felipe Carrera-PinzónDiego Alexander Garzón-Alvarado
May 21, 2020·Arthritis Research & Therapy·Melina BelliniFrank Beier
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ben StaalYu-Wen Zhang
Mar 5, 2019·JBMR Plus·Ling Qin, Frank Beier
Jul 17, 2018·Annals of the New York Academy of Sciences·Purva SinghMiguel Otero
Nov 25, 2020·International Journal of Molecular Sciences·Renpeng FangCarl P Blobel
Aug 30, 2014·Annals of the Rheumatic Diseases·Yun-Peng ZhaoChuan-Ju Liu
Nov 10, 2021·Journal of Bone and Mineral Metabolism·Taizo KanekoTaku Saito
Nov 14, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·John B Lees-ShepardCaroline N Dealy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Xianrong ZhangLing Qin
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Xianrong ZhangLing Qin
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Shirine E UsmaniFrank Beier
© 2021 Meta ULC. All rights reserved