PMID: 1863074Aug 1, 1991

Transforming growth factor alpha expression helps to distinguish keratoacanthomas from squamous cell carcinomas

Archives of Dermatology
T HoE Finzi


Keratoacanthomas may be difficult to distinguish histologically from squamous cell carcinomas. We studied 20 keratocanthomas and 22 squamous cell carcinomas immunohistochemically using an antibody directed against transforming growth factor alpha to determine if the pattern of transforming growth factor alpha expression would provide a useful method of differentiating these tumors. Ninety percent of the keratoacanthomas demonstrated a diffuse pattern within tumor lobules in which all but the most peripheral rim of cells were stained. A similar localization of transforming growth factor alpha was not identified in squamous cell carcinomas. In addition, 40% of the squamous cell carcinomas but none of the keratoacanthomas showed focal transforming growth factor alpha immunostaining. Our results suggest that transforming growth factor alpha expression may be a marker of epithelial differentiation and may help distinguish between these two tumors.


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Dec 3, 1992·The New England Journal of Medicine·D S Preston, R S Stern
May 1, 1995·Clinical and Experimental Dermatology·J J GrantP H McKee
Jul 1, 1995·Critical Reviews in Oncology/hematology·D S SalomonN Normanno
Jun 15, 2010·Clinics in Dermatology·Christine J Ko
May 26, 2007·The American Journal of Pathology·Laure RittiéJames T Elder
Jul 7, 2007·International Journal of Dermatology·Amel Karaa, Amor Khachemoune

Related Concepts

Squamous Cell Carcinoma
Differential Diagnosis
Dermatologic Disorders
Malignant Neoplasm of Skin
Transforming Growth Factor alpha

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