PMID: 8601697Apr 1, 1996Paper

Transforming growth factor-alpha immunoreactivity during induced hair follicle growth cycles in sheep and ferrets

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
A J NixonA J Pearson

Abstract

Transforming growth factor-alpha (TGF-alpha) has been associated with cell proliferation of keratinocytes and implicated in hair growth. We therefore examined changes in the immunocytochemical localization of TGF-alpha and cell proliferation markers in the skin of two unrelated species in which hair cycles could be induced, to elucidate the role of this growth factor in the control of fiber growth. Skin was collected from melatonin-treated ferrets (Mustela putorius furo), untreated Romney sheep (Ovis aries), and New Zealand Wiltshire sheep in which interruption of wool growth had been photoperiodically induced. Immunostaining patterns were very similar in ferrets and sheep. TGF-alpha immunoreactivity was observed in epithelial tissues of the skin but was not co-localized with cell proliferation markers. In anagen follicles, specific staining was most intense in the innermost cells of the outer root sheath and cortical cells in the keratogenous zone but was absent from inner root sheath or dermal papilla. TGF-alpha immunostaining diminished during catagen, although faint staining was retained in all epithelial cells. In telogen and early proanagen follicles, staining remained faint or was restricted to cells on the margin of the...Continue Reading

Citations

Nov 10, 2007·Veterinary Dermatology·A L MartinR L Hullinger
Apr 26, 2003·The Journal of Biological Chemistry·Kingston K L Mak, Siu Yuen Chan

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