PMID: 8944561Oct 1, 1996Paper

Transforming growth factor-alpha in vivo stimulates epithelial cell proliferation in digestive tissues of suckling rats

Gut
K Hormi, T Lehy

Abstract

The role that exogenous transforming growth factor-alpha (TGF-alpha) may exert on cell proliferation in vivo is poorly understood. To investigate the effect of rat TGF-alpha on epithelial cell proliferation in all suckling rat digestive tissues and to compare it with that of rat epidermal growth factor (EGF). ANIMAL AND METHODS: TGF-alpha and EGF were given three times daily either subcutaneously (10 or 20 micrograms/kg) or intraperitoneally (100 micrograms/kg) to rats from the ninth postnatal day. Cell proliferation was assessed through 5-bromo- 2-deoxyuridine incorporation and estimation of labelling indices. For both growth factors, the highest dose given for only two days significantly increased stomach and intestinal weights compared with controls (p < 0.05 to p < 0.001). The proliferative responded depended on the dose given, colonic mucosa being the most sensitive whereas oxyntic mucosa remained unresponsive. TGF-alpha was as potent as EGF in stimulating epithelial cell proliferation in antral, duodenal, and colonic mucosae. However, EGF was more active on oesophageal and jejunal cell proliferation whereas TGF-alpha was more active on pancreatic exocrine cell proliferation and the differences between the two growth facto...Continue Reading

References

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Citations

Feb 29, 2000·Journal of Pediatric Surgery·R A FalconeB W Warner
Dec 25, 2002·Journal of Pediatric Gastroenterology and Nutrition·Renata StepánkováHelena Tlaskalová- Hogenová
Sep 13, 2008·Acta Histochemica Et Cytochemica·Tohru MiyataMinoru Haga
Oct 13, 2006·Journal of Pediatric Gastroenterology and Nutrition·Christiane SchaefferCharlotte Foltzer-Jourdainne
May 5, 2001·Scandinavian Journal of Gastroenterology·H ShinoharaB Dvorák
Mar 19, 2014·Seminars in Cell & Developmental Biology·Bhuminder Singh, Robert J Coffey
Feb 3, 1999·Annals of the New York Academy of Sciences·M Bajaj-ElliottT T Macdonald
Aug 13, 1999·The American Journal of Physiology·D W PowellA B West
Jun 5, 1998·The American Journal of Physiology·M GökeD K Podolsky
Dec 31, 2002·The Journal of Surgical Research·Igor SukhotnikEitan Shiloni

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