PMID: 7541781Jul 1, 1995Paper

Transforming growth factor-beta 1 expression and phenotypic modulation in the kidney of hypertensive rats

Hypertension
A HamaguchiH Iwao

Abstract

We have previously reported that renal mRNA levels for transforming growth factor-beta 1, fibronectin, and collagens were increased in 32-week-old stroke-prone spontaneously hypertensive rats (SHRSP) with severe nephrosclerosis. To elucidate the mechanism of hypertension-induced nephrosclerosis, we examined gene expression and localization of transforming growth factor-beta 1 and cellular phenotype in the kidney of 25-week-old SHRSP with moderate renal damage. Renal mRNA was measured by Northern blot analysis. The localization of transforming growth factor-beta 1 and cellular phenotype was determined by immunohistochemistry. In the kidney of 25-week-old SHRSP, renal transforming growth factor-beta 1 mRNA was elevated compared with Wistar-Kyoto rats (WKY), whereas renal collagen mRNAs of SHRSP were not increased. Immunoreactive transforming growth factor-beta 1 in SHRSP was mainly localized in glomerular cells. Furthermore, alpha-smooth muscle actin and desmin were significantly expressed in SHRSP glomerular cells, in contrast to negligible expression of these proteins in WKY. alpha-Smooth muscle actin staining was also observed in interstitial cells, and vimentin, another phenotypic marker, was expressed in atrophic tubular cel...Continue Reading

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Citations

Jul 16, 1997·European Journal of Pharmacology·A HamaguchiH Iwao
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Pamela HardingSteven D Scherer
Mar 10, 2000·Cytokine & Growth Factor Reviews·K Sharma, T A McGowan
Jul 2, 1998·Kidney International·A MeyrierP Simon
Nov 18, 1997·Clinical and Experimental Pharmacology & Physiology·K HayashiY Kagitani
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masashi NambaHiroshi Iwao
Nov 14, 1997·Kidney International·C GruppG A Müller
Oct 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G T ShinD Kim
Dec 10, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alain Meyrier
Sep 11, 2012·Seminars in Nephrology·Irini Tossidou, Mario Schiffer
Feb 21, 2018·International Journal of Molecular Sciences·Ching HuangShin-Da Lee
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T MiyazakiT Niwa
Sep 19, 1998·International Journal of Experimental Pathology·M ChengT Taguchi
Jan 14, 2011·American Journal of Physiology. Renal Physiology·Jan M WilliamsRichard J Roman
Dec 15, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Paolo GelosaLuigi Sironi
Dec 14, 2002·Cardiovascular Drug Reviews·Katsufumi MizushigeTakahisa Noma

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