PMID: 7539249Jan 1, 1995Paper

Transforming growth factor beta 1 inhibits IL-3- and IL-4-dependent mouse connective tissue-type mast cell proliferation

Archives of Dermatological Research
N ToyotaH Iizuka

Abstract

Transforming growth factor beta 1 (TGF beta 1) is a regulator of cell proliferation and differentiation. Using a mouse peritoneal cell-derived mast cell culture system, we investigated the effects of TGF beta 1 on mast cell proliferation. TGF beta 1 inhibited IL-3- and IL-4-dependent connective tissue-type mast cell proliferation. The effect was concentration dependent: 50% inhibition was observed with 1.0 ng/ml TGF beta 1 and the maximal inhibitory effect (no proliferation), was observed with 10 ng/ml. Flow cytometric analysis suggested that the inhibitory effect of TGF beta 1 was due to blocking of both G1 and G2 phases. Both control and TGF beta 1-treated mast cells showed similar histamine release induced by the calcium ionophore, A23187. TGF beta 1 seems to be an important negative regulator of connective tissue-type mast cell proliferation with apparently no appreciable effect on mast cell function.

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Citations

Jun 21, 2014·Cellular Immunology·Travis W FaberJohn J Ryan
Nov 3, 2005·Experimental Hematology·Mohit KashyapJohn J Ryan
Jun 7, 2017·European Journal of Immunology·Karla A Ramírez-ValadezClaudia González-Espinosa
Sep 11, 2004·International Journal of Dermatology·Biljana Ristić
Mar 3, 2012·Biological & Pharmaceutical Bulletin·Hirotsugu TakanoSatoshi Tanaka
Sep 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Josephine FernandoJohn J Ryan
Jan 21, 2000·Journal of the European Academy of Dermatology and Venereology : JEADV·A D KatsambaJ L Jorizzo
Feb 13, 2018·Immunological Reviews·Kaori MukaiStephen J Galli
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregorio GomezJohn J Ryan
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei ZhaoLawrence B Schwartz

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