Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint

Scientific Reports
Yingjie LiXing Long

Abstract

Synovial chondromatosis (SC) of temporomandibular joint is rare proliferative disorder featured by the formation of cartilaginous nodules in synovium and joint space. Transforming growth factor beta 3 (TGF-β3) is closely related to chondrogenic differentiation, and might participate in pathogenesis of SC. We discovered that increased quantity of synoviocytes and blood vessels were observed in SC synovium. The vessel wall and sublining fibroblasts were stained positively by the antibodies against TGF-β3, fibroblast growth factor 2 (FGF-2), and CD34. In loose bodies (LBs), TGF-β3 was mainly expressed in chondrocytes and FGF-2 was expressed in chondrocytes, fibroblasts, and vessel walls. Expressions of TGF-β1, TGF-β3, FGF-2, Sox9, Wnt-4, Foxc2, and VEGF-A mRNA were significantly higher in SC synovium. Stimulation of TGF-β3 on synoviocytes increased alkaline phosphatase (ALP) activity and expressions of chondrogenic genes (Sox9, Col2α1, Aggrecan, Wnt-4, and Wnt-11), osteogenic genes (Runx2, Foxc2, osteocalcin, and Col1α1), and VEGF-A, but failed to influence FGF-2 expression. However, the addition of FGF-2 increased TGF-β3 expression. In conclusion, TGF-β3 existed in synovium and LBs of SC, and was responsible for the pathogenesis ...Continue Reading

References

Mar 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·L C DijkgraafR S Liem
Aug 1, 1997·International Journal of Oral and Maxillofacial Surgery·S FujitaN Segami
Aug 18, 2001·Arthritis and Rheumatism·C De BariF P Luyten
Dec 25, 2003·Archives of Histology and Cytology·Kayoko Nozawa-InoueTakeyasu Maeda
Jan 25, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H NagaiM Fukuda
Sep 29, 2006·Journal of Anatomy·Timothy E HardinghamSimon R Tew
Sep 18, 2007·Archives of Oral Biology·Jian LiFan Zhu
Sep 17, 2008·Journal of Endodontics·Rui ZhangBin Peng
Jan 14, 2009·Biochemical and Biophysical Research Communications·Shoichi NakanishiAkira Yamaguchi
Feb 7, 2009·Tissue Engineering. Part B, Reviews·Jiabing FanDong-An Wang
Aug 28, 2009·The British Journal of Oral & Maxillofacial Surgery·Carlos C Goizueta-Adame, Raúl González-García
Jul 8, 2010·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Raquel Guijarro-MartínezJosé Vicente Pascual Gil
Oct 29, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Min-jie ChenXiao-hu Zhang
Dec 20, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Toshinari MikamiYasunori Takeda
Dec 27, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Hiroaki YoshidaShosuke Morita
May 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marie MorilleClaudia N Montero-Menei
Jul 3, 2013·BMC Musculoskeletal Disorders·Wulin YouKunzheng Wang
Jan 1, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yingjie LiXing Long

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Citations

Sep 12, 2018·Orthodontics & Craniofacial Research·Rafaela ScariotAlexandre R Vieira
Oct 6, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yingjie LiXing Long
Mar 24, 2021·The Journal of International Medical Research·Wenyan ZhaoFan Yang

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