Transforming growth factor-beta 3 is required for secondary palate fusion

Nature Genetics
G ProetzelThomas Doetschman

Abstract

Mice lacking TGF-beta 3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and subsequent elimination of the mid-line epithelial seam. No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.

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Related Concepts

Gsc protein, mouse
Cleft Palate, Isolated
Cytoskeletal Proteins
DNA Helix Destabilizing Proteins
Lateral Plate Mesoderm
Mice, Inbred C57BL
Morphogenesis
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Repressor Molecules
Transcription Factor

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