Transforming growth factor-beta: a target for cancer therapy

Journal of Immunotoxicology
Ronan J Kelly, John C Morris

Abstract

Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor that regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immune responses. TGF-beta demonstrates paradoxical action whereby it can function to suppress early tumorigenesis; however, it can also facilitate malignant transformation and stimulate tumor growth by manipulating a more hospitable environment for tumor invasion and the development of metastases. Given the integral role of TGF-beta in transformation and cancer progression, various components of the TGF-beta signaling pathway offer potentially attractive therapeutic targets for cancer treatment. This review focuses on the role of TGF-beta in cancer and discusses both small and large molecule drugs currently in development that target TGF-beta, its receptor and important down stream steps along its signaling pathway.

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Citations

Jul 13, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Jeroen T BuijsTheresa A Guise
Jan 1, 2012·BoneKEy Reports·Jeroen T BuijsTheresa A Guise
Aug 12, 2014·Journal of Immunology Research·Belen Tirado-RodriguezSara Huerta-Yepez
Jul 30, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marcela Esquivel-VelázquezJorge Morales-Montor
Apr 23, 2013·Cellular Signalling·Luqing ZhaoYa Cao
Feb 8, 2013·International Journal of Cancer. Journal International Du Cancer·Vanja SisirakNathalie Bendriss-Vermare
Jun 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna L SmithHeide L Ford
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alex Boye

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