Transforming growth factor-beta and interleukin-10 in breast milk and development of atopic diseases in infants

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
E RigottiD G Peroni

Abstract

Precise relationship between breastfeeding and infant allergy is poorly understood. Objective Aim was to quantify TGF-beta(1) and IL-10 in colostrum and mature milk from allergic and non-allergic mothers and to verify relationship with allergic disease development. Mothers (13 allergics, nine controls) of 22 newborns participated to prospective study on development of children atopy. Colostrum and mature milk were assayed for TGF-beta(1) and IL-10 by ELISA. Children underwent paediatrician evaluation at 6 months of life. Data are presented as median values and range. A significant difference in concentration of TGF-beta(1) between colostrum (330, range 0-3400 pg/mL) and mature milk (215, range 0-2400 pg/mL) was observed in samples from allergic mothers (P=0.015). In mature milk TGF-beta(1) was significantly lower in allergic (215, range 0-2400 pg/mL) than in non-allergic mothers (1059, range 0-6250 pg/mL) (P=0.015). IL-10 was weakly expressed without significant differences between allergic (4.8, range 0-42 and 9.5, range 0-42 pg/mL in colostrum and in mature milk) and non-allergic mothers (0, range 0-42 pg/mL in colostrum and 0, range 0-42 pg/mL in mature milk). After 6 months 46% infants from allergic mothers, but none from c...Continue Reading

References

Apr 1, 1995·Pediatric Research·R GarofaloA S Goldman
Nov 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·G HattevigB Björkstén
Aug 1, 1993·The Pediatric Infectious Disease Journal·A S Goldman
Aug 6, 1998·Biology of the Neonate·R P Garofalo, A S Goldman
Oct 30, 1998·Molecular Medicine Today·P J Barnes, S Lim
May 18, 1999·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J P Buts
Dec 10, 1999·The Journal of Allergy and Clinical Immunology·M KalliomäkiE Isolauri
Jan 7, 2000·Pediatric Research·M F BöttcherB Björkstén
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K G TournoyR A Pauwels
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P J Barnes
Jul 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K M Järvinen, H Suomalainen
Apr 4, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M F Böttcher, Maria C Jenmalm
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Wendy H OddyAnne L Wright

❮ Previous
Next ❯

Citations

Apr 6, 2012·Folia Microbiologica·Jiří HrdýLudmila Prokešová
Mar 18, 2008·The British Journal of Nutrition·Adriana Ortiz-AndrellucchiLluís Serra-Majem
Sep 4, 2013·Pediatric Research·Jessica BurchLaura M Goetzl
Mar 19, 2009·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Samuli Rautava, W Allan Walker
Jul 12, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Tina M SlusherMargaret K Nakakeeto
Jun 2, 2012·Italian Journal of Pediatrics·Diego G PeroniGiorgio L Piacentini
Apr 6, 2011·PloS One·Gerco den HartogR J Joost van Neerven
Feb 15, 2012·Advances in Nutrition·Amanda C Palmer
Jul 4, 2007·The Journal of Allergy and Clinical Immunology·Takashi AndoAtsuhito Nakao
Jun 2, 2007·Journal of Psychosomatic Research·Hajime Kimata
Jan 22, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Diego G PeroniAttilio L Boner
Dec 21, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B E P SnijdersC Thijs
Aug 20, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Diego G PeroniAttilio L Boner
Sep 21, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Naoki KondoZentaro Yamagata
Apr 13, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Intan H IsmailMimi L K Tang
Aug 1, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D MunblitJ O Warner
Feb 14, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Christine L M JosephChristine Cole Johnson
Jul 15, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Wendy H Oddy, Francisco Rosales
Jun 3, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A A JepsenH Bisgaard
Nov 28, 2012·International Archives of Allergy and Immunology·Shingo OchiaiYoichi Kohno
Jun 17, 2011·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Saroochi AgarwalVenu Gangur
Jul 18, 2017·Nutrients·R J J van Neerven, Huub Savelkoul
Aug 18, 2017·Nutrients·Daniel MunblitJohn O Warner
Aug 8, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Chad A LoganJon Genuneit
Apr 28, 2010·Journal of Clinical Gastroenterology·Katrina J Allen, Pamela E Martin
Oct 29, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mikaïl BerdiUNKNOWN EDEN Mother-Child Cohort Study Group
Jan 14, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Nakao
Apr 5, 2014·European Journal of Nutrition·Marta OlivaresYolanda Sanz
May 7, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Ekaterina KhalevaDaniel Munblit
Apr 10, 2014·Clinical Reviews in Allergy & Immunology·Zhanglei MuJianzhong Zhang
Apr 6, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kopperuncholan NamachivayamAkhil Maheshwari
Jun 19, 2018·Frontiers in Pediatrics·Yoshinori MoritaNaoki Shimojo
Jan 29, 2019·Environmental Science and Pollution Research International·Martyna Pajewska-SzmytRenata Gadzała-Kopciuch
Feb 7, 2019·Frontiers in Immunology·Bassel Dawod, Jean S Marshall
Apr 22, 2021·Minerva Pediatrics·Giulia NuzziDiego G Peroni
Jul 3, 2021·International Journal of Molecular Sciences·Anna KiełbasaBogusław Buszewski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Ludmila ProkesováIvan Sterzl
Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Richard KitzHans J Böhles
© 2022 Meta ULC. All rights reserved