PMID: 15387373Sep 25, 2004Paper

Transforming growth factor-beta facilitates breast carcinoma metastasis by promoting tumor cell survival

Clinical & Experimental Metastasis
Qin Yu, I Stamenkovic

Abstract

We have shown recently that the hyaluronan receptor, CD44, and matrix metalloproteinase 9 (MMP-9) form a complex on the surface of TA/St mouse mammary carcinoma cells that activates latent transforming growth factor-beta (TGF-beta) and is required for tumor invasion. Disruption of the CD44/MMP-9 complex by expression of soluble CD44 results in the loss of tumor invasiveness and abrogates tumor cell survival in host lung parenchyma following intravenous injection into syngeneic mice. To explore the molecular nature of the survival signals derived from the CD44/MMP-9 complex during the development of tumor metastasis, we investigated the possibility that activation of latent TGF-beta by the CD44/MMP-9 complex is responsible for tumor cell survival in host lung parenchyma. TA3 cells overexpressing dominant negative soluble CD44 (TA3sCD44), which compromises native CD44 function and the ability of TA3 cells to develop metastases, were transfected with constitutively active or latent TGF-beta2 and tested for their ability to form tumors in syngeneic mice. Our results demonstrate that expression of the constitutively active, but not the latent, form of TGF-beta2 rescues TA3sCD44 cells from apoptosis during lung colonization. These ob...Continue Reading

Citations

Jan 25, 2011·Annals of Hematology·Magdalena Katharina HertweckKarl-Anton Kreuzer
Oct 9, 2008·Breast Cancer Research and Treatment·Antoinette R TanMichael Reiss
Apr 28, 2006·Clinical & Experimental Metastasis·Nandita Bose, Anna M Masellis
Mar 5, 2011·The Journal of Biological Chemistry·Thorsten JungMargot Zöller
May 5, 2005·Journal of Vascular Research·Sarah J GeorgeChristopher L Jackson
Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kiranmai GumireddyQihong Huang
Sep 25, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nathalie ChaputGuido Kroemer
Feb 18, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·T W LiuG Zheng
Nov 18, 2008·The International Journal of Biochemistry & Cell Biology·Elise LambertEmmanuelle Petitfrère-Charpentier
Jun 26, 2014·Molecular Carcinogenesis·Tian HuannaWu Chen
Dec 5, 2014·Archives of Toxicology·V Orian-Rousseau, H Ponta
Feb 1, 2008·Annual Review of Pathology·Marina Bacac, Ivan Stamenkovic
Oct 25, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Evgenia KarousouSpyros S Skandalis
Apr 20, 2013·Experimental Biology and Medicine·Karin WilliamsSusan Kasper
Jan 24, 2007·British Journal of Cancer·T HagemannP O A Van Trappen
Aug 18, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Eugenio HardyCarlos Fernandez-Patron
Aug 29, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gérald J Prud'homme
Aug 8, 2006·Nature Medicine·Patricia S Steeg
Oct 2, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laetitia Charrier-HisamuddinDidier Merlin
Feb 14, 2017·BioMed Research International·Hao LongYe Song
Jan 12, 2019·Cell Death & Disease·Lixin MaPengyu Chang
Oct 18, 2019·International Journal of Molecular Sciences·Mitsuru FutakuchiJunya Fukuoka
Mar 7, 2021·Biomolecules·Margherita SistoSabrina Lisi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis